Evidence map›Paper›PMID 40033086›Full record

ArticleBJC reports2025

Health inequalities in hepatocellular carcinoma surveillance, diagnosis, treatment, and survival in the United Kingdom: a scoping review.

Christopher Mysko, Stephanie Landi, Huw Purssell, A Joy Allen, Martin Prince, Gary Lindsay, Steven Rodrigues, Jenny Irvine, Oliver Street, Deepankar Gahloth and 4 more

Abstract read
In one paragraph

Article in BJC reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christopher MyskoManchester University NHS Foundation Trust, Manchester, UK.ORCID http://orcid.org/0000-0002-2090-7916
Stephanie LandiManchester University NHS Foundation Trust, Manchester, UK.
Huw PurssellManchester University NHS Foundation Trust, Manchester, UK.
A Joy AllenRoche Diagnostics Limited, Welwyn Garden City, UK.
Martin PrinceManchester University NHS Foundation Trust, Manchester, UK.
Gary LindsayVocal, Manchester, UK.
Steven RodriguesVocal, Manchester, UK.
Jenny IrvineVocal, Manchester, UK.
Oliver StreetUniversity of Manchester, Manchester, UK.
Deepankar GahlothUniversity of Manchester, Manchester, UK.
Sara MacLennanUniversity of Aberdeen, Aberdeen, UK.
Karen Piper HanleyUniversity of Manchester, Manchester, UK.
Neil HanleyUniversity of Birmingham, Birmingham, UK.
Varinder Singh AthwalManchester University NHS Foundation Trust, Manchester, UK. varinder.athwal@manchester.ac.uk.ORCID http://orcid.org/0000-0002-1684-721X

Funding

NHS Cancer Programme NCPC02013
6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) remains a deadly cancer in the UK despite advancements in curative therapies. Societal conditions and health inequalities influence the development of chronic liver disease and outcomes from complications including HCC. Scoping this emergent evidence-base is required to inform research and solutions for the NHS.

methodsA PRISMA scoping review was performed up to September 2023. Articles exploring health inequalities in HCC involving the UK population were included.

resultsThis review has characterised axes of health inequality and their impact across the HCC care continuum in the UK. Studies predominantly employed a cohort design or population-based analyses, with meta-analyses of surveillance utilisation including only a single UK study. These methodologies provided an appropriate lens to understand longitudinal trends and identify disadvantaged groups. However, important evidence gaps remain, including exploration of patient perspectives, intersectional analyses, and statistical measures of socioeconomic inequity in HCC.

conclusionsHCC is a rapidly growing cause of cancer mortality and disproportionally affects underserved groups, presenting a major public health concern. Further research is required to innovate and evaluate surveillance and management pathways to reduce systemic inequities. Direction is needed at the national level to improve prevention, early diagnosis and access to curative treatment.

Identifiers

PMID40033086
PMCPMC11876667

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.