Evidence map›Paper›PMID 40033077›Full record

ArticlePediatric research2026

The association between fractalkine/CX3CR1 axis with IgA vasculitis and nephritis.

Rui Gu, Yuanzhao Zhi, Aoyu Wang, Daojing Ying, Huiqin Zeng, Peipei Shi, Lu Cao, Jianjiang Zhang, Qin Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rui GuDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China.
Yuanzhao ZhiDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China.
Aoyu WangDepartment of Medical Record Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Daojing YingDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China.
Huiqin ZengDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China.
Peipei ShiDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China.
Lu CaoDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China.
Jianjiang ZhangDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China. zhangjianjiang1@hotmail.com.
Qin WangDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Clinical Center of Pediatric Nephrology of Henan Province, Zhengzhou, China. 18337138873@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study investigated whether the fractalkine/CX3CR1 axis is associated with the presence and severity of IgA vasculitis (IgAV) and IgA vasculitis nephritis (IgAVN) in children.

methodsWe included 59 children with IgAV, 42 children with IgAVN (including 18 children with kidney biopsy), 26 plasma controls and 8 kidney controls. Clinical pathological data were collected, and the fractalkine/CX3CR1 axis and macrophage expression in the circulation and kidneys were detected.

resultsCirculating fractalkine/CX3CR1 axis expression was significantly upregulated in children with IgAV and IgAVN compared to healthy controls. Plasma fractalkine levels and the proportion of CX3CR1

conclusionThe expression of fractalkine/CX3CR1 axis is associated with the presence and severity of IgAV and IgAVN. Our findings support further investigation of fractalkine/CX3CR1 as a target for future therapies in IgAV and IgAN. IMPACT: The expression of plasma fractalkine/CX3CR1 axis is associated with the presence and severity of IgAV and IgAVN. The expression of kidney fractalkine/CX3CR1 axis and macrophage are upregulated in IgAVN, which is closely associated with poorer kidney function and more severe kidney pathology. Our findings support further investigation of fractalkine/CX3CR1 as a target for future therapies in IgAV and IgAVN.

Indexed as

Chemokine CX3CL1CX3C Chemokine Receptor 1Glomerulonephritis, IGAImmunoglobulin ANephritisVasculitisAdolescentAntigens, CDAntigens, Differentiation, MyelomonocyticCase-Control StudiesCD68 MoleculeChildChild, PreschoolFemaleHumansKidneyAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 MoleculeChemokine CX3CL1CX3C Chemokine Receptor 1CX3CL1 protein, humanCX3CR1 protein, humanImmunoglobulin A

Identifiers

PMID40033077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.