ArticleNature metabolism2025
A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence.
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Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
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29 citing papers in PubMed.
- High-Dose Vitamin D3 Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- Genetic investigation of the association between maternal dietary patterns and offspring ADHD.Molecular psychiatry · 2026Article
- Breastfeeding type is associated with urinary metabolic changes in early life: influence of sex and early weight gain in healthy term infants.Molecular and cellular pediatrics · 2026Article
- Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment.Journal of translational medicine · 2026Review
- Maternal Diet During Pregnancy and Offspring Health: Current Evidence on Dietary Patterns, Microbiota, and Developmental Programming.Nutrients · 2026Review
- Metabolomic alterations in cord blood improve the prediction of childhood-onset neurodevelopmental disorders.Translational psychiatry · 2026Article
- Maternal Microbiome in Fetal Programming: A One Health Perspective on Translational Implications for Early-Life Health.Microorganisms · 2026Review
- Assessment of the dietary and nutritional status of Iranian pregnant women: a study employing both a priori and a posteriori analytical approaches.Scientific reports · 2026Article
- Effects of pre- and postnatal probiotic and ω-3 fatty acid supplementation on cytokine and chemokine responses to allergens and TLR ligands during infancy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Western dietary pattern during pregnancy and early childhood increases risk of childhood asthma dependent on socioeconomic status.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Maternal metabolic signatures at early gestation associated with birth weight and neurodevelopment in early childhood.Communications medicine · 2026Article
- Maternal 12-HETE is associated with childhood asthma and the responses to prenatal omega-3 supplementation.Cell reports. Medicine · 2026Article
- Article
- Cord serum metabolic signatures associated with neonatal anthropometry and neurodevelopment through age two in twins.iScience · 2026Article
- Longitudinal metabolome profiling from pregnancy through childhood and risk of neurodevelopmental disorders at age 10.Nature communications · 2026Article
- Dietary inflammatory index (DII) and attention deficit hyperactivity disorder: a cross-sectional study in US children and adolescents and Mendelian randomization study.European journal of medical research · 2026Article
- Maternal high-fat diet and risk of cardiovascular disease in offspring: a review of mechanisms, controversies, and interventions.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Beyond breastfeeding: a One Health Decalogue for nurturing the infant microbiota.Frontiers in nutrition · 2026Review
- A risk prediction model for autism spectrum disorder integrating biopsychosocial factors: a systematic review and meta-analysis with multicenter validation.Translational pediatrics · 2025Article
- Maternal mid-pregnancy dietary patterns and inflammatory bowel disease in offspring from a prospective cohort study.Communications medicine · 2025Article
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Authors and funding
29 authors.
David HornerCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. david.horner@dbac.dk.ORCID http://orcid.org/0000-0002-0200-4561
Jens Richardt M JepsenCenter for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Bo ChawesCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Kristina AagaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Julie B RosenbergCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Parisa MohammadzadehCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Astrid SevelstedCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Nilo VahmanCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Rebecca VindingCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Birgitte FagerlundCenter for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.ORCID http://orcid.org/0000-0003-4547-2944
Christos PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia.ORCID http://orcid.org/0000-0002-9565-0238
Niels BilenbergInstitute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Casper-Emil T PedersenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2540-5373
Anders EliasenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2629-0790
Sarah BrandtCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Yulu ChenChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nicole PrinceChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8506-1122
Su H ChuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6345-008X
Rachel S KellyChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3023-1822
Jessica Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Thorhallur I HalldorssonFaculty of Food Science and Nutrition, School of Health Science, University of Iceland, Health Science Institute, Unit for Nutrition Research, Reykjavík, Iceland.
Marin StrømDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Katrine Strandberg-LarsenSection of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Sjurdur F OlsenDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Birte Y GlenthøjCenter for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.ORCID http://orcid.org/0000-0003-3056-7262
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2003-1018
Bjørn H Ebdrup *Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Jakob Stokholm *COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4989-9769
Morten Arendt Rasmussen *COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. morten.arendt@dbac.dk.ORCID http://orcid.org/0000-0001-7431-5206
Funding
Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0MOmic Determinants of Longitudinal Lung Function in AsthmaR01HL155742 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A, MCGEACHIE, MICHAEL JOHN · 2021 to 2025
$3.9MMechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomicsR01HL141826 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2018 to 2021
$3.4MMulti-Omic Endotyping of AsthmaK01HL146980 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KELLY, RACHEL SABINE · 2019 to 2023
$891kIntegrative metabolomic characterization of ADHD and asthma comorbidityK01HL153941 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHU, SU HEE · 2020 to 2024
$891kInflammatory subtypes and multi-omic determinants of early life infection riskK01HL175261 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Nicole Prince · 2024 to 2026
$533kLundbeckfonden (Lundbeck Foundation) R269-2017-5NHLBI NIH HHS K01 HL146980NHLBI NIH HHS K01 HL153941NHLBI NIH HHS K01 HL175261NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL141826NHLBI NIH HHS R01 HL155742
Abstract
Despite the high prevalence of neurodevelopmental disorders, the influence of maternal diet during pregnancy on child neurodevelopment remains understudied. Here we show that a western dietary pattern during pregnancy is associated with child neurodevelopmental disorders. We analyse self-reported maternal dietary patterns at 24 weeks of pregnancy and clinically evaluated neurodevelopmental disorders at 10 years of age in the COPSAC2010 cohort (n = 508). We find significant associations with attention-deficit hyperactivity disorder (ADHD) and autism diagnoses. We validate the ADHD findings in three large, independent mother-child cohorts (n = 59,725, n = 656 and n = 348) through self-reported dietary modelling, maternal blood metabolomics and foetal blood metabolomics. Metabolome analyses identify 15 mediating metabolites in pregnancy that improve ADHD prediction. Longitudinal blood metabolome analyses, incorporating five time points per cohort in two independent cohorts, reveal that associations between western dietary pattern metabolite scores and neurodevelopmental outcomes are consistently significant in early-mid-pregnancy. These findings highlight the potential for targeted prenatal dietary interventions to prevent neurodevelopmental disorders and emphasise the importance of early intervention.
Indexed as
Diet, WesternNeurodevelopmental DisordersPrenatal Exposure Delayed EffectsAdolescentAdultAttention Deficit Disorder with HyperactivityChildCohort StudiesFemaleHumansLongitudinal StudiesMaleMetabolomeMetabolomicsPregnancy
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