ArticleArthritis & rheumatology (Hoboken, N.J.)2025
Peripheral Biomarker Signatures in Rheumatoid Arthritis-Associated Interstitial Lung Disease.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence and influencing factors of progressive pulmonary fibrosis in connective tissue disease-associated interstitial lung disease: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Malondialdehyde-acetaldehyde modified macromolecules and resulting autoantibodies in rheumatoid arthritis pathogenesis: a Systematic Literature Review.Frontiers in immunology · 2025Pooled it
- Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis-Associated Interstitial Lung Disease Risk.Arthritis care & research · 2026Observational
- Association of Plasma miRNA-7-5p and miRNA-214-5p With Rheumatoid Arthritis Associated Interstitial Lung Disease.International journal of rheumatic diseases · 2026Article
- Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model.The Journal of pharmacology and experimental therapeutics · 2026Article
- Diagnostic, prognostic and therapeutic biomarkers in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Heterogeneity of Rheumatoid Arthritis-Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations With Disease Outcomes.Arthritis care & research · 2026Article
- Advances in the Diagnosis of Rheumatoid Arthritis-Associated Interstitial Lung Disease: Integrating Conventional Tools and Emerging Biomarkers.International journal of molecular sciences · 2026Review
- Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications.Frontiers in immunology · 2026Review
- Chemerin in Pulmonary Fibrosis: Advances in Mechanistic and Fundamental Research.Biomolecules · 2025Review
- Clinical application of combined anticoagulation therapy in anti-MDA5 antibody-positive associated interstitial lung disease-a retrospective study.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
objectiveRheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA-ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA-ILD discrimination beyond clinical and genetic risk factors.
methodsWe performed a cross-sectional study of participants in the Veterans Affairs Rheumatoid Arthritis Registry. ILD was validated through systematic record review. Autoantibodies (n = 14), proinflammatory cytokines/chemokines (n = 36), adipokines (n = 3), alarmins (n = 3), and matrix metalloproteinases (n = 9) were measured from banked serum or plasma. MUC5B rs35705950 genotyping was obtained via microarray. Principal component (PC) analysis was performed to derive unique biomarker signatures. Logistic regression was used to compare models predicting RA-ILD presence using combinations of clinical, peripheral biomarker, and genetic variables.
resultsAmong 2,001 participants with RA (88.7% male, mean age 63.7 years), 121 (6.4%) had RA-ILD. A total of 15 PCs were identified, with 8 significantly associated with RA-ILD after adjusting for clinical factors. These eight included biomarker themes of innate and allergic responses, autoantibodies (anti-cyclic citrullinated peptide, rheumatoid factor, anti-malondialdehyde-acetaldehyde adduct), adipokines, alarmins, tissue remodeling, and neutrophil chemotaxis. Models with PCs (area under the receiver operating characteristic curve [AUC] 0.739) and PCs with MUC5B (AUC 0.751) outperformed clinical risk factors alone (AUC 0.630; P < 0.001).
conclusionPeripheral biomarker signatures are associated with RA-ILD and improve RA-ILD identification beyond clinical risk factors. In addition to demonstrating the potential for peripheral biomarkers to aid RA-ILD risk stratification, these findings suggest diverse pathways are involved in RA-ILD pathogenesis.
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