ArticleScientific reports2025
Serum ferritin levels and risk of gestational diabetes mellitus: A cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Nutrition, Physical Activity and Other Health Aspects Before and During Pregnancy - Recommendations by the Nationwide "Healthy Start Network" (Netzwerk Gesund ins Leben) 2026.Geburtshilfe und Frauenheilkunde · 2026Article
- Physiologically based ferritin thresholds to redefine early pregnancy iron screening: a cross-sectional study.Scientific reports · 2026Article
- Association Between Longitudinal Serum Ferritin and Gestational Diabetes Mellitus - Beijing, Shanxi, and Shandong PLADs, China, 2021-2024.China CDC weekly · 2026Article
- First-trimester ferritin levels and gestational diabetes mellitus risk in twin pregnancies: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Analyzing the association between ferritin levels and ICP using machine learning algorithms: a retrospective case-control study.Frontiers in medicine · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Gestational diabetes mellitus (GDM) is a glucose metabolism disorder with an unclear etiology that occurs specifically during pregnancy. While elevated serum ferritin levels have been reported to increase the risk of GDM, these findings lack validation in large-scale studies and have yet to inform clinical practice effectively. This study enrolled 12,434 controls and 3599 GDM patients and employed binary multifactorial logistic regression, restricted cubic spline, propensity score matching, and a random forest algorithm to explore the relationship between serum ferritin and GDM, as well as the effect size of ferritin on GDM. The results indicated that GDM patients have higher serum ferritin levels compared to controls in the second and third trimesters. A weak correlation was found between serum ferritin levels and OGTT 1-hour and 2-hour blood glucose levels in the second trimester. Logistic regression (LR) and restricted cubic spline (RCS) analyses showed a significant positive correlation between serum ferritin levels and GDM in the second and third trimesters. Propensity score matching analysis indicated that the association between second-trimester serum ferritin levels and GDM remained nearly constant before and after matching. The random forest algorithm suggested that among all confounders, serum ferritin had a minimal effect on GDM risk. In conclusion, our study provides further compelling evidence for the association between serum ferritin levels and gestational diabetes mellitus. However, additional research is still needed to clarify the specific mechanisms underlying this association.
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