ArticleScientific reports2025
Disrupted topological organization of brain connectome in patients with chronic low back related leg pain and clinical correlations.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Altered Structural Brain Connectivity in Postherpetic Neuralgia and its Association with Neuropathic Pain Severity: A Diffusion Tensor Imaging Study.Brain topography · 2026Article
- Convergent structural brain alterations in chronic pain: a multi-metric individual participant data meta-analysis.Brain communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Chronic pain is associated with persistent alterations in brain structure and function. However, existing research has not fully explored the relationship between brain network topological properties and clinical symptoms in patients with chronic low back-related leg pain (cLBLP). In this study, we collected resting-state functional and structural magnetic resonance imaging data, along with clinical symptom evaluation data, from 32 cLBLP patients and 31 healthy controls. A large-scale complex network analysis was conducted to evaluate the global and nodal topological properties of functional and structural brain networks. Statistical analyses were performed to determine the associations between network properties and clinical variables. The results showed significant alterations in both global and nodal topological properties of functional and structural brain networks in cLBLP patients compared to healthy controls. Additionally, a direct correlation was found between structural network properties and spatial discrimination ability, measured by two-point tactile discrimination values, while no significant association was observed between functional connectivity and spatial discrimination. This study demonstrates that cLBLP patients exbibit a decreased local efficiency of functional connectivity network and increased compensatory global efficiency of structural connectivity network. Notably, alterations in the structural connectome, rather than the functional connectome, play a more significant role in deterioration of foot tactile spatial acuity in cLBLP patients. Trial registration: This trial was registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2200055321 on 2022-01-06.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.