ArticleScientific reports2025
Nonlinear association between serum 25-hydroxyvitamin D concentrations and lung function in the United States adult population with COPD.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Association between underdiagnosed and overdiagnosed chronic obstructive pulmonary disease with all-cause mortality.Journal of thoracic disease · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D has been studied for its potential protective effects against lung function decline in patients with COPD. However, conflicting results exist, the actual effect of vitamin D on lung function remains controversial. This study aimed to determine whether serum 25-hydroxyvitamin D (25-OHD) levels are correlated with lung function in community-dwelling individuals with COPD. We used data from the National Health and Nutrition Examination Survey (NHANES) to explore the relationship between serum 25-OHD concentration and the severity of airflow obstruction. Multivariable logistic regression, stratified analysis with interaction, restricted cubic splines (RCS), and threshold effect analysis were used to investigate the association between serum 25-OHD concentration and lung function.A total of 1384 patients with COPD were analyzed. Accordingly, the association between serum 25-OHD concentrations and lung function exhibited an inverse L-shaped curve in the RCS. Threshold analysis showed that in participants with 25-OHD concentrations < 90 nmol/L, lung function decreased with decrease in serum 25-OHD concentrations, whereas no significant association was observed in those with serum 25-OHD concentrations ≥ 90 nmol/L. An inverse L-shaped relationship was observed between serum 25-OHD concentration and airflow obstruction severity in the adult population with COPD in the United States.
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