Evidence map›Paper›PMID 40032873›Full record

ArticleScientific reports2025

Modifying the severity and appearance of psoriasis using deep learning to simulate anticipated improvements during treatment.

Joseph Scott, James A Grant-Jacob, Matthew Praeger, George Coltart, Jonathan Sutton, Michalis N Zervas, Mahesan Niranjan, Robert W Eason, Eugene Healy, Ben Mills

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph ScottDermatology, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK.
James A Grant-JacobOptoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK.
Matthew PraegerOptoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK.
George ColtartDermatology, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK.
Jonathan SuttonDermatology, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK.
Michalis N ZervasOptoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK.
Mahesan NiranjanLearning and Control Group, University of Southampton, Southampton, SO17 1BJ, UK.
Robert W EasonOptoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK.
Eugene Healy *Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK. e.healy@soton.ac.uk.
Ben Mills *Optoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK. bm602@orc.soton.ac.uk.

Funding

Engineering and Physical Sciences Research Council EP/T026197/1Engineering and Physical Sciences Research Council EP/W028786/1National Institute for Health and Care Research AI_AWARD02168National Institute for Health and Care Research NIHR303694
6 · The paper itself

Abstract

A neural network was trained to generate synthetic images of severe and moderate psoriatic plaques, after being trained on 375 photographs of patients with psoriasis taken in a clinical setting. A latent w-space vector was identified that allowed the degree of severity of the psoriasis in the generated images to be modified. A second latent w-space vector was identified that allowed the size of the psoriasis plaque to be modified and this was used to show the potential to alleviate bias in the training data. With appropriate training data, such an approach could see a future application in a clinical setting where a patient is able to observe a prediction for the appearance of their skin and associated skin condition under a range of treatments and after different time periods, hence allowing an informed and data-driven decision on optimal treatment to be determined.

Indexed as

Deep LearningPsoriasisAdultFemaleHumansMaleMiddle AgedNeural Networks, ComputerSeverity of Illness IndexDeep learningGenerative artificial intelligenceImage processingNeural networkPersonalised medicinePsoriasis

Identifiers

PMID40032873
PMCPMC11876654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.