ArticleHormones (Athens, Greece)2025
The deleterious effect of bisphenol S on early embryo development of mice.
Article in Hormones (Athens, Greece), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- The silent crisis: investigating the impact of environmental pollutants on embryo-fetal development: a narrative review of the Group of Special Interest for Environment of the Italian Society of Fertility and Sterility and Reproductive Medicine.Journal of assisted reproduction and genetics · 2025Review
- GLP-1 agonists on a roll: from obesity to psoriasis - an elixir to watch!Hormones (Athens, Greece) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIncreasing levels of infertility in Western countries has drawn ever more scientific attention to the role in this trend of endocrine disruptors, such as bisphenol A, a substance now banned in some cases and some countries. Because this substance has been replaced by the structurally similar bisphenol S (BPS), this study focused on the effects of the latter on early mice embryo development.
methodsCultures of CD1 mice embryos with varying concentrations of BPS were compared with control blank cultures in order to examine the survival rate of embryos according to BPS concentration and culture day.
resultsThe administration of BPS at any dose (1, 10, and 100 pg/ml) in cultures of mice embryos led to a significant decrease in their survival rate. The negative effect of BPS was seen to start early (day 1 of experiment), even with the lowest employed dose (1 pg/ml).
conclusionsThis is, to the best of our knowledge, the first study to investigate the impact of BPS on the survival rate of mice embryos. In this study, potential adverse effects of BPS on early CD1 mice embryo development with regard to survival rate have been identified. Dose of BPS, timing of BPS administration, and time duration of exposure play a critical role in the decrease of mice embryo survival rate as compared to control cultures. These findings raise concerns regarding the safety of BPS and highlight the need for further research into the effect of this substance on human embryos.
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