Evidence map›Paper›PMID 40032754›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Cognitive markers of resilience to dementia in mild Neurocognitive Impairment: a meta- analysis.

Simona Raimo, Mariachiara Gaita, Maria Cropano, Lidia Ammendola, Daniela Malangone, Valentina Torchia, Mariamichela Aquino, Maria Dolores Roldan-Tapia, Luigi Trojano, Gabriella Santangelo

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In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Simona RaimoDepartment of Psychology, University of Campania 'Luigi Vanvitelli', Caserta, Italy. simona.raimo@unicz.it.ORCID http://orcid.org/0000-0002-0687-9656
Mariachiara GaitaDepartment of Psychology, University of Campania 'Luigi Vanvitelli', Caserta, Italy.
Maria CropanoDepartment of Health Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.
Lidia AmmendolaUOSD Second Neurology, Multiple Sclerosis Center, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Daniela MalangoneDepartment of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.
Valentina TorchiaDepartment of Health Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.
Mariamichela AquinoDepartment of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.
Maria Dolores Roldan-TapiaDepartment of Psychology, University of Almería, Almería, Spain.
Luigi TrojanoDepartment of Psychology, University of Campania 'Luigi Vanvitelli', Caserta, Italy.
Gabriella SantangeloDepartment of Psychology, University of Campania 'Luigi Vanvitelli', Caserta, Italy.

Funding

Programma Operativo Nazionale Ricerca e Innovazione 2014-2020 Activity Code: AIM 1813080-2
6 · The paper itself

Abstract

backgroundNumerous risk factors for dementia have been identified, but the concern of how cognitive functions in the mild Neurocognitive Impairment (mild NCI) stage predict dementia occurrence and incidence is still a matter of debate. The present paper aims to fill this gap by conducting an updated meta-analysis of studies examining the probability over time of developing dementia in relation to measures of global cognitive functioning, long-term verbal memory, complex attention, visuoconstructional ability, and language in the mild NCI stage.

methodsWe conducted a systematic literature search up to March 2024 in PubMed, PsycINFO (PROQUEST), and Scopus databases. We used random-effects models to pool the ratio measure (odds, hazard, or risk ratios) for the association between cognitive domains and the risk of developing dementia in people with mild NCI.

resultsThe systematic search in electronic databases identified 44 relevant studies. Results showed that better performance in long-term verbal memory, visuoconstructional, and language abilities in individuals with mild NCI were associated with a lower risk of progression to dementia. DISCUSSION: These findings might suggest that interventions aimed at preserving or enhancing these cognitive domains could be beneficial in delaying or preventing dementia onset, offering a potential therapeutic target for clinicians working with at-risk populations.

Indexed as

Cognitive DysfunctionDementiaResilience, PsychologicalDisease ProgressionHumansCognitive functionsDementiaMeta-analysisMild neurocognitive impairment

Identifiers

PMID40032754

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.