Evidence map›Paper›PMID 40032662›Full record

Trial reportSurgical endoscopy2025

Intraoperative autonomic neural blockade: comparison between different local anesthetics combinations: a randomized clinical trial.

Jorge Daes, Rafael Pantoja, Elika Luque, Andrés Hanssen, Jose Rocha, Eric M Pauli

3 registry-linked trialsAbstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06137924 phase3unknown statusnot on this map

Intraoperative Autonomic Neural Blockade (ANB) Comparison Between Different Local Anesthetic Combinations. A Randomized Clinical Trial Protocol

TypeinterventionalSponsorUniversidad Simón BolívarRan2023 to 2024Enrolled150ConditionsPain, Postoperative, Nausea, Postoperative, Vomiting, Postoperative, AnalgesiaArmsLocal anesthetic injection Bupivacaine plus dexamethasone, Local anesthetic injection bupivacainde plus dexamethasone plus a colloid, Local anesthetic injection bupivacaine plus clonidine
NCT07104825 narecruitingnot on this mapstarted 2026, after this paper: background citation

Autonomic Neural Blockade During Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial Evaluating Pain and Nausea After Bariatric Surgery

TypeinterventionalSponsorEndeavor HealthRan2026 to 2027Enrolled200ConditionsBariatric Surgery Candidate, Pain, Postoperative, Nausea and Vomiting, Postoperative, Opioid UseArmsIntraoperative autonomic neural blockade (ANB), Laparoscopic Standard of Care Abdominal Wall Block
NCT07655908 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Targeted Temporary In Situ Catheter Redosing of Autonomic Neural Blockade for Breakthrough Symptoms After Laparoscopic Sleeve Gastrectomy

TypeinterventionalSponsorUniversidad Simón BolívarRan2026 to 2027Enrolled30ConditionsPain, Acute Post-Operative, Nausea and Vomiting, PostoperativeArmsBupivacaine 0.5% and Dexamethasone via Temporary Catheter
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jorge DaesDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Clínica Iberoamérica, Carrera 50 No 79-223 PH B, 850020, Barranquilla, Colombia. jorgedaez@gmail.com.ORCID http://orcid.org/0000-0002-3125-6602
Rafael PantojaDepartment of Anesthesia, Clínica Iberoamérica, Barranquilla, Colombia.
Elika LuqueDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Clínica Iberoamérica, Carrera 50 No 79-223 PH B, 850020, Barranquilla, Colombia.
Andrés HanssenDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Clínica Iberoamérica, Carrera 50 No 79-223 PH B, 850020, Barranquilla, Colombia.
Jose RochaSchool of Surgical Instrumentation, Universidad Simon Bolivar, Barranquilla, Colombia.
Eric M PauliDivision of Minimally Invasive and Bariatric Surgery, Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvances in minimally invasive techniques, enhanced recovery protocols, and regional pain management have improved postoperative outcomes. However, visceral pain and postoperative nausea and vomiting (PONV) remain challenging, particularly after laparoscopic sleeve gastrectomy (LSG) and other minimally invasive procedures. Intraoperative autonomic neural blockade (ANB) has demonstrated efficacy in addressing these issues, with the duration of the effect its most important limitation.

methodsThis randomized clinical trial (RCT) evaluated the effectiveness of three anesthetic combinations used during ANB for LSG. The combinations were Bupivacaine + Clonidine (B + C), Bupivacaine + Dexamethasone (B + D), and Bupivacaine + Dexamethasone + Gelofusine (B + D + G). 160 patients were randomly assigned to one of the three groups. Pain levels, PONV, and the need for additional analgesics were assessed at 1, 8, 24, and 36 h postoperatively.

resultsThere was no statistical difference among the groups with low pain levels, PONV, and analgesic consumption across all anesthetic combinations. No complications were reported. Opioid consumption was lower in all three combinations than in our index study using only 0.5% bupivacaine. Pain levels peaked at 24 h and decreased significantly by 36 h, especially in the B + D + G group. The B + D + G group achieved the highest percentage of "perfect result" patients, with no pain, no PONV, and no need for additional analgesics.

conclusionsThis study demonstrates the safety and efficacy of intraoperative ANB using different anesthetic combinations in LSG patients without statistical significance among the groups. The B + D + G group achieved the lowest 36-h pain levels and the highest percentage of "perfect results," although the clinical relevance is tentative. The progressive reduction in opioid use highlights ANB's role in improving patient safety. The findings may inform adjustments to enhanced recovery after surgery (ERAS) protocols and support integrating ANB into clinical practice to improve postoperative outcomes in LSG patients.

trial registrationThe protocol was registered in ClinicalTrials.gov under the identifier NCT06137924.

Indexed as

Anesthetics, CombinedAnesthetics, LocalAutonomic Nerve BlockGastrectomyLaparoscopyPostoperative PainAdultBupivacaineClonidineDexamethasoneFemaleHumansMaleMiddle AgedPain MeasurementPostoperative Nausea and VomitingAnesthetics, CombinedAnesthetics, LocalBupivacaineClonidineDexamethasoneAutonomic neural blockadeLocal anestheticsOpioidsPostoperative nausea and vomitingVisceral pain

Identifiers

PMID40032662

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.