ArticleAccounts of chemical research2025
The Photoactivated Depot (PAD): Light Triggered Control of Therapeutic Protein Solubility and Release.
Article in Accounts of chemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Blood Cell-Based Drug Delivery Systems: From Biological and Mechanical Design to Clinical Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Pulsatile Release of Human Gonadotropin Releasing Hormone Using a Photoactivated Depot Containing an Unusual Light Cleaved Functionality.Molecular pharmaceutics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Many therapeutic proteins can benefit from controlling the timing and amount of their release. This is especially true for signaling molecules such as insulin, whose requirements vary continually throughout the day. Currently, the only way to provide this variable delivery is through a pump. Pumps, and their required cannulas/needles, introduce a wide range of problems, including cannula occlusion, infection, and biofouling. We have instead pursued the photoactivated depot or PAD approach, in which therapeutic proteins are released into the body through light activation of shallow, skin-based depots that are activated by small LED light sources (
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Registered trials
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