Evidence map›Paper›PMID 40032531›Full record

ArticleeNeuro2025

Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function.

Alexander W Lehr, Thien A Nguyen, Wenyan Han, Eunhye Hong, John D Badger, Wei Lu, Katherine W Roche

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexander W LehrReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Thien A NguyenReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Wenyan HanSynapse and Neural Circuit Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.ORCID https://orcid.org/0000-0003-0886-1430
Eunhye HongReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
John D BadgerReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Wei LuSynapse and Neural Circuit Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.ORCID https://orcid.org/0000-0001-6668-8432
Katherine W RocheReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 rochek@ninds.nih.gov.

Funding

The regulation of synaptic transmission and neural circuit functionZIANS003136 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LU, WEI · 2012 to 2025
$27.0M
Regulation of Neuroligins and Effects on Synapse Number and FunctionZIANS003140 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROCHE, KATHERINE · 2014 to 2025
$20.5M
Intramural NIH HHS ZIA NS003136Intramural NIH HHS ZIA NS003140
6 · The paper itself

Abstract

Neuroligins (NLGNs) are a family of postsynaptic adhesion molecules that bind to their presynaptic partners, neurexins, facilitating the formation and maintenance of synapses. In humans, there are five genes encoding NLGNs (

Indexed as

Cell Adhesion Molecules, NeuronalDendritic SpinesNeuronsSynapsesAnimalsCells, CulturedCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase 5HippocampusHumansMicePhosphorylationRatsCell Adhesion Molecules, NeuronalCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase 5autism spectrum disorderneuroliginphosphorylationsex-linkedspine morphologyspinogenesis

Identifiers

PMID40032531
PMCPMC11913403

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.