Evidence map›Paper›PMID 40032522›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.

Margaret M Donahue, Emma Robson, Laura Lee Colgin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Margaret M DonahueCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas 78712 colgin@mail.clm.utexas.edu.ORCID https://orcid.org/0000-0002-9356-3720
Emma RobsonCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas 78712.
Laura Lee ColginCenter for Learning and Memory, The University of Texas at Austin, Austin, Texas 78712 colgin@mail.clm.utexas.edu.ORCID https://orcid.org/0000-0002-4853-8913

Funding

Investigating mechanisms underlying impaired social and spatial cognition in rodent models of Fragile X syndromeR01MH131317 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H, COLGIN, LAURA L · 2022 to 2025
$3.0M
Physiological mechanisms underlying disrupted hippocampal function in Fragile X syndromeR56MH125655 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H, COLGIN, LAURA L · 2021 to 2022
$1.2M
Mechanisms underlying impaired hippocampal physiology in Fragile X SyndromeF31MH127933 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI DONAHUE, MARGARET MCNEIL · 2022 to 2023
$88k
NIMH NIH HHS F31 MH127933NIMH NIH HHS R01 MH131317NIMH NIH HHS R56 MH125655
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is a neurodevelopmental disorder that can cause impairments in spatial cognition and memory. The hippocampus is thought to support spatial cognition through the activity of place cells, neurons with spatial receptive fields. Coordinated firing of place cell populations is organized by different oscillatory patterns in the hippocampus during specific behavioral states. Theta rhythms organize place cell populations during awake exploration. Sharp wave-ripples organize place cell population reactivation during waking rest. Here, we examined the coordination of CA1 place cell populations during active behavior and subsequent rest in a rat model of FXS (

Indexed as

CA1 Region, HippocampalFragile X SyndromeHippocampusPlace CellsAnimalsDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1MaleRatsRats, Long-EvansTheta RhythmFmr1 protein, ratFragile X Messenger Ribonucleoprotein 1Fragile X syndromehippocampusplace cellsreplaysharp wave-rippletheta

Identifiers

PMID40032522
PMCPMC11984088

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.