Evidence map›Paper›PMID 40032383›Full record

ArticleBMJ open2025

Effect of electroacupuncture on the incidence of acute stroke after embolisation of intracranial aneurysm: study protocol for a single-centre, double-blinded, randomised controlled trial.

Zi-Jian Zhao, Hang Wang, Qian Ye, Zhen-Feng Zhang, Shi-Yang Dong, Yi-Fan Xu, Jing-Jin Li, Min Yu, Feng Feng

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zi-Jian Zhao *Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.ORCID http://orcid.org/0009-0000-1504-1065
Hang Wang *Department of Anesthesiology, University of Health and Rehabilitation Sciences, Qingdao, Shibei District, China.
Qian YeRehabilitation Medicine Centre, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Zhen-Feng ZhangDepartment of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Shi-Yang DongDepartment of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Yi-Fan XuDepartment of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Jing-Jin LiDepartment of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Min Yu *Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Feng Feng *Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China fengfeng1988@njmu.edu.cn.ORCID http://orcid.org/0009-0001-3209-7156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectroacupuncture (EA) is commonly used in clinical settings as a significant method for treating a variety of pain and cerebrovascular disorders. Despite its widespread use, there is limited information on the impact of perioperative EA on postoperative stroke. This study aimed to investigate whether preoperative EA therapy could reduce the occurrence of acute stroke in patients undergoing interventional surgery for intracranial aneurysms. METHODS/

designThis single-centre, double-blind, placebo-controlled, randomised clinical trial aims to recruit 280 patients undergoing embolisation of intracranial aneurysms under general anaesthesia. Participants will be randomly assigned to either the EA group or sham electroacupuncture (SEA) group. The EA group will receive treatment half an hour before surgery, while the SEA group will receive sham acupuncture. The primary outcome will be the occurrence of acute stroke within 7 days post surgery. Secondary outcomes include the incidence of symptomatic and occult stroke within the same timeframe, the occurrence of cerebral vasospasm during the operation and the number of intraoperative cerebrovascular dissections. ETHICS AND DISSEMINATION: This study has been approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University (2023-SR-538.A1). The study started on 17 May 2024, and it is expected to end on 31 March 2025. The results of our study will be published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: ChiCTR2300076960.

Indexed as

ElectroacupunctureEmbolization, TherapeuticIntracranial AneurysmPostoperative ComplicationsStrokeAdultAgedDouble-Blind MethodFemaleHumansIncidenceMaleMiddle AgedRandomized Controlled Trials as TopicAnaesthesia in neurologyElectric Stimulation TherapyIntracerebral HemorrhageNeurosurgeryStroke

Identifiers

PMID40032383
PMCPMC11877269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.