Evidence map›Paper›PMID 40032364›Full record

ArticleBMJ open2025

Biochemical use of neurofilament light polypeptide and vitamin B

Mathilde Thrysøe, Tina Parkner, Hatice Tankisi, Jens Randel Nyengaard, Esben Thyssen Vestergaard, Kurt Kristensen, Astrid Juhl Terkelsen, Vinni Faber Rasmussen

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In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mathilde ThrysøeDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark maljsp@rm.dk.ORCID http://orcid.org/0000-0002-3557-6566
Tina ParknerDepartment of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Hatice TankisiDepartment of Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
Jens Randel NyengaardCore Centre for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Esben Thyssen VestergaardDepartment of Pediatric and Adolescents Medicine, Aarhus University Hospital, Aarhus, Denmark.
Kurt KristensenSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Astrid Juhl TerkelsenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Vinni Faber RasmussenDepartment of Pediatrics and Adolescents, Randers Regional Hospital, Randers, Denmark.ORCID http://orcid.org/0000-0002-1356-2833

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to investigate serum Neurofilament Light polypeptide (NfL) as a biomarker for diabetic polyneuropathy (DPN) in adolescents with type 1 diabetes (T1D). Secondarily, to investigate vitamin B RESEARCH DESIGN AND

methodsCross-sectional study. Sixty Danish adolescents with T1D (age 15-18 years, diabetes duration >5 years) and 23 age-matched control subjects were included. Based on nerve conduction studies (NCS), intraepidermal nerve fibre density (IENFD) and neurological examination, patients were divided into three groups: (1) T1D without DPN, (2) T1D with subclinical DPN and (3) T1D with confirmed DPN. Blood levels of NfL, B

resultsTwenty-four of the adolescents were without DPN, twenty-one had subclinical DPN and eight had confirmed DPN. NCS was not conducted in three participants and four patients did not have blood samples taken. There were no significant differences in NfL levels or any of the B

conclusionsNfL used in a cross-sectional manner was not found useful to distinguish between the adolescents with DPN and those without. Vitamin B

Indexed as

Diabetes Mellitus, Type 1Diabetic NeuropathiesNeurofilament ProteinsVitamin B 12Vitamin B 12 DeficiencyAdolescentBiomarkersCase-Control StudiesCross-Sectional StudiesDenmarkFemaleHumansMaleMethylmalonic AcidNeural ConductionBiomarkersMethylmalonic Acidneurofilament protein LNeurofilament ProteinsVitamin B 12AdolescentDiabetic neuropathyPaediatric endocrinologyPaediatric neurology

Identifiers

PMID40032364
PMCPMC11883878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.