Evidence map›Paper›PMID 40032157›Full record

Trial reportBrain stimulation

Acute dentate nucleus deep brain stimulation modulates corticomotor excitability in chronic stroke survivors.

Xin Li, Kenneth B Baker, Kyle O'Laughlin, Yin-Liang Lin, Kelsey Baker, Robert Chen, Jacqueline Chen, Andre G Machado, Ela B Plow

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Research progress on the neuromodulation targets in stroke rehabilitation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin LiDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Kenneth B BakerCenter for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Kyle O'LaughlinDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Yin-Liang LinDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Kelsey BakerDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, Rio Grande Valley, TX, USA.
Robert ChenKrembil Research Institute, University Health Network, Toronto, ON, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Jacqueline ChenDepartment of Diagnostic Radiology, Diagnostics Institute, Cleveland Clinic, Cleveland, OH, USA.
Andre G MachadoCenter for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Ela B PlowDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Rehabilitation Hospitals, Department of Physical Medicine and Rehabilitation, Cleveland Clinic, Cleveland, OH, USA. Electronic address: plowe2@ccf.org.

Funding

Deep cerebellar electrical stimulation for post-stroke motor recoveryUH3NS100543 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2016 to 2021
$4.9M
Contralaterally Controlled FES Combined with Brain Stimulation for Severe Upper limb HemiplegiaR01HD098073 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, ELA B · 2019 to 2024
$3.1M
NICHD NIH HHS R01 HD098073NINDS NIH HHS UH3 NS100543
6 · The paper itself

Abstract

backgroundDeep brain stimulation of the dentate nucleus (DN-DBS) is an emerging therapy to improve upper extremity (UE) motor function after stroke. This study sought to investigate the physiologic mechanisms of acute DN-DBS in chronic stroke survivors enrolled in a phase I trial for DN-DBS.

methodsTwelve chronic stroke participants with moderate-to-severe UE impairment received (acute) single sessions (≥45 min) of active DBS and sham DBS in a sham-controlled, double-blind, cross-over experiment (order randomized). Transcranial magnetic stimulation (TMS) was used to evaluate corticomotor physiology. We also characterized the relationship between acute DBS effects on physiology and baseline clinical and neuroimaging measures, and chronic DBS effects on motor function.

resultsAcute active DBS led to an increase in ipsilesional corticomotor excitability evident as a 5.2 % maximal stimulator output (MSO) reduction in active motor threshold (p = 0.017, d = 0.28), but there was no effect of acute sham DBS. Increases in corticomotor excitability observed with acute DBS were associated with higher microstructural integrity of ipsilesional corticospinal tract (r > 0.70, p < 0.017) and dentato-thalamo-cortical pathways (ρ > 0.69, p < 0.022). Gains in corticomotor excitability with acute DBS were associated with higher dexterity gains made with chronic DBS plus rehabilitation (r > 0.65, p < 0.028).

conclusionsAcute DN-DBS leads to heightened ipsilesional corticomotor excitability in moderate-to-severe chronic stroke survivors. Effects of acute DN-DBS on physiology are contingent upon structural preservation of key white matter tracts and associated with motor gains made with chronic DN-DBS. Findings provide mechanistic support of DN-DBS as a potential therapy for post-stroke motor recovery and potential of TMS to monitor responses.

Indexed as

Cerebellar NucleiDeep Brain StimulationMotor CortexStrokeAgedChronic DiseaseCross-Over StudiesDouble-Blind MethodEvoked Potentials, MotorFemaleHumansMaleMiddle AgedStroke RehabilitationSurvivorsTranscranial Magnetic StimulationDeep brain stimulationDentate nucleusNeurophysiologyStrokeTranscranial magnetic stimulationUpper extremity

Identifiers

PMID40032157
PMCPMC12216442

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.