N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) as a novel chelator for Wilson's disease.

Rajitha Gadde, Shrey Shah, Mark Böhlke, Jonghan Kim, Swati Betharia

Abstract read

In one paragraph

Article in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rajitha GaddeDepartment of Pharmaceutical Sciences, MCPHS University, School of Pharmacy, Boston, MA, USA.

Shrey ShahDepartment of Pharmaceutical Sciences, MCPHS University, School of Pharmacy, Boston, MA, USA.

Mark BöhlkeDepartment of Pharmaceutical Sciences, MCPHS University, School of Pharmacy, Boston, MA, USA.

Jonghan KimDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, MA, USA.

Swati BethariaDepartment of Pharmaceutical Sciences, MCPHS University, School of Pharmacy, Boston, MA, USA. Electronic address: swati.betharia@mcphs.edu.

Funding

Reversal of copper accumulation for the early prevention of Wilson’s diseaseR21HD110731 · NICHD · UNIVERSITY OF MASSACHUSETTS LOWELL · PI BETHARIA, SWATI, KIM, JONGHAN · 2022 to 2023

$412k

NICHD NIH HHS R21 HD110731

6 · The paper itself

Abstract

Wilson's Disease (WD) is a rare autosomal recessive disorder caused by mutations in the ATP7B gene. These mutations lead to defective copper (Cu) transport and to accumulation of Cu in tissues, primarily in the liver and brain. Current treatment options such as D-penicillamine, trientine, and zinc salts focus on increasing Cu excretion or reducing Cu absorption, but often cause debilitating side effects. N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) is a lipophilic thiol-based compound originally developed for environmental decontamination. It has been shown to chelate toxic metals such as mercury, lead, and cadmium. This study was designed to evaluate the efficacy of NBMI to mitigate Cu overload using both in vitro and in vivo models of WD. HepG2 cells with the ATP7B gene knocked down had increased sensitivity to copper sulfate (CuSO

Indexed as

Chelating AgentsHepatolenticular DegenerationPhthalic AcidsAdenosine TriphosphatasesAnimalsCation Transport ProteinsCopperCopper SulfateCopper-Transporting ATPasesDisease Models, AnimalHep G2 CellsHumansLiverMaleMiceAdenosine TriphosphatasesATP7B protein, humanAtp7b protein, mouseCation Transport ProteinsChelating AgentsCopperCopper SulfateCopper-Transporting ATPasesPhthalic AcidsChelationCopper overloadNBMIToxic milk mouseWilson's disease

Identifiers

PMID40032031

DOI10.1016/j.freeradbiomed.2025.02.046

PMCPMC12817343

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.