Evidence map›Paper›PMID 40031966›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[GPSM2 is highly expressed in gastric cancer to affect patient prognosis by promoting tumor cell proliferation].

Xue Song, Yue Chen, Min Zhang, Nuo Zhang, Lugen Zuo, Jing Li, Zhijun Geng, Xiaofeng Zhang, Yueyue Wang, Lian Wang and 1 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xue SongCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Yue ChenCollege of Laboratory Medicine, Bengbu Medical University, Bengbu 233000, China.
Min ZhangCollege of Laboratory Medicine, Bengbu Medical University, Bengbu 233000, China.
Nuo ZhangCollege of Laboratory Medicine, Bengbu Medical University, Bengbu 233000, China.
Lugen ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Jing LiDepartment of Laboratory Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Zhijun GengCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Xiaofeng ZhangCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Yueyue WangDepartment of Laboratory Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Lian WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Jianguo HuDepartment of Laboratory Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the association between GPSM2 expression level and gastric cancer progression and analyze the functional pathways and action mechanism of GPSM2.

methodsWe analyzed GPSM2 expression levels in gastric cancer tumors based on data from the GEPIA database and the clinical data of 109 patients. Public databases enrichment analysis were used to assess the impact of GPSM2 expression level on survival outcomes and the functional pathways and action mechanism of GPSM2. We further observed the effects of GPSM2 knockdown and overexpression on proliferation, migration and apoptosis of MGC803 cells using CCK-8 assay, colony formation assay, flow cytometry and immunoblotting and on the growth of MGC803 cell xenografts in nude mice.

resultsBioinformatic analysis and immunohistochemical staining of the clinical specimens both revealed high GPSM2 expressions in gastric cancer (

conclusionsGPSM2 is highly expressed in gastric cancer to affect patient prognosis by promoting tumor cell proliferation and G1/S transition possibly

Indexed as

Cell ProliferationStomach NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementHumansMiceMice, NudePrognosisTumor Suppressor Protein p53Tumor Suppressor Protein p53cell cyclegastric cancerGPSM2p53prognosis

Identifiers

PMID40031966
PMCPMC11875856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.