Evidence map›Paper›PMID 40031947›Full record

ReviewCanadian Urological Association journal = Journal de l'Association des urologues du Canada2025

Association of absolute amount of pattern 4 disease on prostate biopsy with oncologic outcomes in intermediate-risk prostate cancer A systematic review.

Melissa Sam Soon, Scott C Morgan, Luke T Lavallée, Rodney H Breau, Trevor A Flood, Mark T Corkum

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melissa Sam SoonUniversity of Ottawa, Ottawa, ON, Canada.
Scott C MorganDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Physics, University of Ottawa and the Ottawa Hospital, Ottawa, ON, Canada.
Luke T LavalléeDivision of Urology, Department of Surgery, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Rodney H BreauDivision of Urology, Department of Surgery, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Trevor A FloodDepartment of Anatomical Pathology, University of Ottawa and the Ottawa Hospital, Ottawa, ON, Canada.
Mark T CorkumDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Physics, University of Ottawa and the Ottawa Hospital, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionManaging intermediate-risk prostate cancer is challenging due to the heterogeneity in patient outcomes within this risk category. Evaluating the absolute amount of Gleason pattern 4 disease (GP4) at biopsy using the total linear length of pattern 4 (GP4-TL) or absolute percentage of pattern 4 (APP4) may enhance risk stratification. This review aimed to determine if these absolute measures predict oncologic outcomes in IRPC and to identify optimal prognostic thresholds.

methodsA systematic review was conducted following PRISMA guidelines. Studies included were those reporting the absolute amount of GP4 on biopsy and related outcomes in IRPC patients undergoing surgery or radiotherapy. Outcomes included biochemical recurrence, androgen deprivation therapy (ADT)-free survival, distant metastasis, prostate cancer-specific mortality, all-cause mortality, and adverse pathology.

resultsSeven studies with a total of 2523 patients were included. Analysis revealed that APP4 thresholds were highly predictive of biochemical recurrence, ADT-free survival, and distant metastasis. Both APP4 and GP4-TL were superior to relative % GP4 and Gleason grading (4+3 vs. 3+4) in predicting disease progression and mortality.

conclusionsThe absolute amount of GP4 shows consistent associations with important clinical outcomes and offers an accessible and established method to enhance risk stratification. Further research is needed to define optimal thresholds to guide treatment decisions.

Identifiers

PMID40031947
PMCPMC12158451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.