Evidence map›Paper›PMID 40031928›Full record

ArticleJournal of cellular and molecular medicine2025

Quantification of All-Trans Retinoic Acid and Cytokine Levels After Fungal, Viral and Bacterial Infections in the Lung.

Samuel A Krug, Ravineel Singh, Jianshi Yu, William T Witt, Nageswara R Pilli, Angela Wilks, Mariette Barbier, Keven M Robinson, Maureen A Kane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel A KrugDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
Ravineel SinghDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jianshi YuDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
William T WittVaccine Development Center, West Virgina University Health Sciences Center, Morgantown, West Virginia, USA.
Nageswara R PilliDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
Angela WilksDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
Mariette BarbierVaccine Development Center, West Virgina University Health Sciences Center, Morgantown, West Virginia, USA.
Keven M RobinsonDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Maureen A KaneDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0002-5525-9170

Funding

TASK ORDER B-1, ANIMAL MODEL DEVELOPMENT AND EFFICACY TESTING OF CANDIDATE MCMS75N93020D00011 · NIAID · SRI INTERNATIONAL · 2020 to 2025
$86.2M
Mechanistic characterization and regulation of the non-redundant phu and has heme uptake systems of Pseudomonas aeruginosaR01AI134886 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Angela Wilks · 2018 to 2026
$3.0M
Influenza Attenuates Innate Pulmonary Host Defense against Invasive Pulmonary AspergillosisR01AI153337 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBINSON, KEVEN MARA · 2021 to 2025
$2.7M
National Institute of Allergy and Infectious Diseases AI134886-01National Institute of Allergy and Infectious Diseases R01AI153337NIAID NIH HHS 75N93020D00011NIAID NIH HHS R01 AI134886NIAID NIH HHS R01 AI153337University of Maryland School of Pharmacy Mass Spectrometry Center SOP1841-IQB2014
6 · The paper itself

Abstract

All-trans retinoic acid (atRA) plays a critical role in tissue homeostasis as a master regulator of cellular proliferation, apoptosis and differentiation as well as in immune cell differentiation and function. An active metabolite of vitamin A, atRA has been reported to be reduced in a number of inflammatory conditions in both the lung and gut. Decreases in atRA have been reported in gastrointestinal tissue in inflammatory bowel diseases, radiation-induced gastrointestinal injury and viral infection. In the lung, atRA is reduced in inflammatory conditions including allergic asthma and radiation-induced lung injury; however, the impact of infection on lung atRA is not well defined. In this short communication, we quantified atRA and cytokine levels in the lung after fungal, viral and bacterial infections in mice and determined the correlation between atRA and cytokine levels in the lung. atRA was quantified by LC-MRM

Indexed as

Bacterial InfectionsCytokinesLungTretinoinVirus DiseasesAnimalsAspergillus fumigatusFemaleMiceMice, Inbred C57BLPseudomonas aeruginosaCytokinesTretinoinAspergillus fumigatuscytokineInfluenza Alungmass spectrometrymethicillin‐resistant Staphylococcus aureusPseudomonas aeruginosaretinoic acid

Identifiers

PMID40031928
PMCPMC11875669

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.