ArticleNeurology2025
Association Between Changes in White Matter Volume Detected With Diffusion Tensor-Based Morphometry and Motor Recovery After Stroke.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Surgery versus Botulinum Toxin A for Treatment of Post-Stroke Upper-Limb Spasticity: White Matter Changes, Function, and Quality-of-Life-A Randomized Controlled Trial.Neural plasticity · 2026Trial
- Association Between Changes in White Matter Volume Detected With Diffusion Tensor-Based Morphometry and Motor Recovery After Stroke.Neurology · 2025Article
- Volume changes in white matter pathways from infancy to early adulthood measured using diffusion tensor based morphometry.Frontiers in neurology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesDiffusion tensor-based morphometry (DTBM) provides a more accurate assessment of volumetric changes in white matter structures than conventional T1-based TBM techniques. We sought to determine whether DTBM could detect volume loss in the corticospinal tract (CST) and whether this marker was associated with impaired stroke recovery.
methodsRetrospective clinical MRI scans were obtained from a cohort of participants enrolled in a natural history study with acute anterior circulation ischemic stroke and unilateral arm impairment (NIH Stroke Scale [NIHSS] arm motor item score ≥2). Maps of the change in fractional anisotropy (delta FA) and the DTBM log of the Jacobian (LnJ, representing volumetric change) between scans, acquired <36 hours and 30 days after stroke, were computed. Voxel-wise Spearman rank-based analysis identified clustered regions of interest (ROIs) where the delta FA and LnJ from baseline to 30 days correlated with individual arm motor recovery scores on the NIHSS from baseline to 30 days. Qualitative comparisons were made between delta FA and LnJ maps for good and poor recovery groups (delta NIHSS arm item score ≥2 or <2, respectively) in reference to controls.
resultsTwenty-one participants with anterior circulation stroke were evaluated (mean age 63.6 years, median NIHSS arm motor item score 4, 48% female). Voxel-wise statistical maps identified 2 ROIs for delta FA and 4 ROIs for LnJ showing strong correlations with arm motor recovery (range of Spearman ρ = 0.77-0.81, all DISCUSSION: DTBM detects focal volume loss in the CST over the first 30 days after stroke likely related to Wallerian degeneration. These volumetric changes may provide complementary information to FA in characterizing white matter loss after stroke. Like FA, DTBM shows strong correlations with arm motor recovery that could be useful for predicting recovery after stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.