ArticleHistochemistry and cell biology2025
Expression of angiogenic factors in the mammalian senescent cell sustaining Trichinella spp. muscle larvae.
Article in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Comparative proteomic analysis of the angiogenic response in an in vitro model of vascular endothelial cells to excretory/secretory and somatic antigens of Dirofilaria immitis.Parasites & vectors · 2026Article
- Endothelial proteomic response to Dirofilaria repens somatic antigens and the Dr20/22 protein reveals parasite-driven modulation of angiogenesis.Parasites & vectors · 2026Article
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8 authors.
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Abstract
Muscle larvae of the mammalian parasitic nematode Trichinella spp. live in a senescent nurse cell (NC). The NC is formed from a portion of the invaded myofiber and muscle satellite cells that fuse with it. In continuation of our previous research, which documented a senescent phenotype in a fully developed NC analyzed 7 months post-infection, we show in this current study that cellular senescence is a primary event during NC establishment, and occurs as early as 26 days post-infection. At both stages of the formation process, 26 days and 7 months post-infection, the NC was found to express angiogenic factors: angiopoietin 2, interleukin 1β, matrix metallopeptidase 2, platelet-derived growth factor D, and vascular endothelial growth factor C. We hypothesize that the nuclei of the degenerating myofiber transforms the senescent program to the fusing satellite cells. Hypersecretory activity of the senescent NC may facilitate the development of a circulatory rete, which has long been known to accompany the formation of the NC-larva complex.
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