Exploring the biomechanical response of human semicircular canals by a visualized bionic model.

Yani Jiang, Xianhua Wen, Guangcheng Xiang, Wenxuan Zhang, Junjie Dai, Junjie Gong, Yixiang Bian

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Article in European biophysics journal : EBJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Yani JiangCollege of Mechanical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu, China.

Xianhua WenCollege of Mechanical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu, China.

Guangcheng XiangCollege of Mechanical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu, China.

Wenxuan ZhangCollege of Mechanical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu, China.

Junjie DaiCollege of Mechanical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu, China.

Junjie GongCollege of Mechanical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu, China. jj_gong@yeah.net.

Yixiang BianCollege of Mechanical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu, China. yxBian@yzu.edu.cn.ORCID http://orcid.org/0000-0002-3933-9605

Funding

Key Technologies Research and Development Program 2024YFD2000203

6 · The paper itself

Abstract

At present, research on the biomechanical response of the cupula of human semicircular canals (HSCs) has focused on indirect inference through the nystagmus view, which is limited by the participation of the human nervous system. In this study, 3D printing technology and hydrogel modification methods were used to fabricate a one-dimensional bionic semicircular canal (BSC) model with a ratio of 1:1 to the horizontal HSC. Target tracking technology was used to observe the deformation of the cupula. Then, constant angular acceleration stimulation and the other two stimulations were separately applied to the BSC to explore its biomechanical response. The results showed that the BSC had a similar time constant to that of the HSC, its maximum deviation displacement was proportional to the applied angular acceleration, and its amplitude-frequency gain under sinusoidal oscillation stimulation increased, but its phase difference decreased with increasing frequency, which consistent with the conclusions obtained by our theoretical deduction. The BSC model is expected to play a certain role in the mechanistic research and disease diagnosis of HSCs.

Indexed as

BionicsMechanical PhenomenaModels, BiologicalSemicircular CanalsBiomechanical PhenomenaHumansAngular accelerationBionic semicircular canal model (BSC)Deviation displacement of the cupulaHuman semicircular canal (HSCs)

Identifiers

PMID40029423

DOI10.1007/s00249-025-01738-y

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.