ArticleAnnals of medicine2025
Persistence of scrub typhus IgM and IgG antibodies among patients from Karnataka, India.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Scrub and murine typhus seroprevalence among blood donors in Laos.PLoS neglected tropical diseases · 2026Article
- Diagnostic heterogeneity in scrub typhus serology: A scoping review of IFA thresholds and regional standardisation needs (2005-2024).PLoS neglected tropical diseases · 2025Article
- Risk factors for scrub typhus infection in South India: population-based cohort study.Epidemiology and infection · 2025Observational
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe longevity of scrub typhus IgM and IgG are not clear. A region-specific diagnostic cut-off for enzyme-linked immunosorbent assay (ELISA) is a necessity for improved diagnosis.
objectivesTo determine a region-specific optical density (OD) value cut-off for scrub typhus IgM and IgG ELISA and to study the persistence of these antibodies.
methodsA prospective cohort study was conducted among patients diagnosed with scrub typhus admitted to Kasturba Hospital, Manipal, Karnataka, India from August 2019 to April 2023. An equal number of scrub typhus patients and healthy volunteers were enrolled to determine region-specific scrub typhus IgM and IgG ELISA OD value cut-off. A receiver operating characteristic (ROC) curve analysis was performed to determine the OD value cut-off with an optimal combination of sensitivity and specificity. The patients were followed up prospectively at varying time points up to 18 months and scrub typhus IgM and IgG ELISA were performed in all the collected samples.
resultsThe ROC curve analysis of scrub typhus IgM revealed an optimal OD value cut-off of 1.309 with a sensitivity and specificity of 98.7% (95% CI: 93.1%-100%). The ROC curve analysis of scrub typhus IgG revealed an optimal OD value cut-off of 0.9 with a sensitivity of 71.7% (95% CI: 60.5%-81.4%) and specificity of 93.5% (95% CI: 85.7%-97.9%). At 18 months of follow-up, scrub typhus IgM (OD value > 1.309) and IgG (OD value > 0.9) were above the newly derived diagnostic cut-off in 17 (32%) and 40 (75.4%) patients, respectively.
conclusionScrub typhus IgM and IgG antibodies were persistent above the newly derived regional diagnostic cut-off for up to 18 months.
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