ArticleMovement disorders : official journal of the Movement Disorder Society2025
Comparative Study of Focused Ultrasound Unilateral Thalamotomy and Subthalamotomy for Medication-Refractory Parkinson's Disease Tremor.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of MRI-guided focused ultrasound lesioning for tremor-dominant Parkinson Disease: A systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Subthalamic Nucleus Deep Brain Stimulation Improves Kinetic Tremor in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Dual-target magnetic resonance-guided focused ultrasound of the subthalamic and ventral intermediate nuclei for Parkinson's disease: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026Review
- Contralateral Spread of Asymmetrical Tremor in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Advanced Therapeutics in Parkinson's Disease: What's New?Current neurology and neuroscience reports · 2026Review
- Longitudinal Blood-Biomarker-Based Assessment of Brain Injury in Patients Undergoing Deep Brain Stimulation and Magnetic Resonance-Guided Focused Ultrasound.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Long-term outcomes after caudal zona incerta-forel field ablation: three-year clinical follow-up in advanced Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Immediate Motor Control Enhancement via Pallidothalamic Tract (PTT) Circuit Ablation: A Dual-Target MR-Guided Focused Ultrasound Approach for Tremor-Dominant Parkinson's Disease.European journal of neurology · 2025Article
- Lesion of the Subthalamic Nucleus Should Not be Labeled "Subthalamotomy"; A Plea for Anatomical Accuracy and Compliance with Historical Legacy.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Does Dopamine Sensitivity Influence the Choice between Subthalamotomy and Thalamotomy for Parkinsonian Tremor?Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Unilateral focused ultrasound thalamotomy for tremor-dominant Parkinson's disease: blinded evaluation and imaging correlation.Brain communications · 2025Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnilateral focused ultrasound ventral intermediate thalamotomy (Vim-FUS) is effective in treating Parkinson's disease (PD) tremor. Ultrasound ablation of the subthalamic nucleus (STN-FUS) has demonstrated efficacy in improving all cardinal motor features of PD, including tremor.
objectiveTo compare the efficacy in parkinsonian tremor control between Vim-FUS and STN-FUS.
methodsRetrospective, two-center study including consecutive PD patients with medication-refractory tremor who underwent unilateral Vim-FUS or STN-FUS between June 2015 and August 2022. Patients scored ≥2 for postural and/or resting tremor on the most affected body side in the off-medication state. The primary outcome was the between-group difference in tremor improvement on the treated side at 12-month follow-up, including a responder's analysis. Data regarding safety, global motor status, and dopaminergic requirements were also collected. Group comparisons used repeated measures ANOVA with Bonferroni correction; statistical significance for P < 0.05.
resultsAmong 175 patients treated at the two sites, 63 were included (23 Vim-FUS, 40 STN-FUS). At baseline, both groups were equivalent in disease duration (6.7 ± 3.8 vs. 6.1 ± 3.4 years, P = 0.48) and tremor severity (5.7 ± 1.5 vs. 5.9 ± 2.5, P = 0.7). While the benefit in tremor was equivalent between the groups at 4 months (P = 0.15), tremor reduction was greater in STN- FUS patients at 12 months (4.4 ± 2.0, 95% CI 3.7-5.0 compared with 2.7 ± 3.7, 95% CI 1.1-4.3 for Vim-FUS, P = 0.012). In 47.5% (19/40) of STN-FUS patients tremor was completely abolished versus 8.7% (2/23) in Vim-FUS patients (P < 0.01). Most adverse events were mild (91%) and resolved by 12 months.
conclusionsSTN-FUS and Vim-FUS significantly improved medication-refractory PD tremor; however, subthalamotomy might have greater and more sustained effect. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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