ArticleJournal of the American Heart Association2025
Estimated Pulse Wave Velocity and Stroke Among Middle-Aged and Older Population: Insights From 3 Prospective Cohorts.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of estimated pulse wave velocity with cardiovascular disease outcomes and all-cause death-a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Nonlinear Associations of Estimated Pulse Wave Velocity With Hepatic Steatosis and Liver Stiffness in Community-Based People.Gastroenterology research · 2026Article
- Development of an Oral Health Index and Its Association with Oral Health-Related Quality of Life and Cardiovascular Risks: A Cross-Sectional Study.International journal of environmental research and public health · 2026Observational
- Pulsatility index: Insights into post-stroke haemodynamics.Neuroscience insights · 2026Review
- High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later.Neurobiology of aging · 2025Article
- Mediating role of arterial stiffness in the association between physical activity and cardiovascular disease risk: a prospective cohort study.Scientific reports · 2025Article
- Association Between Cumulative Estimated Pulse Wave Velocity and the Risk of Major Adverse Cardiovascular Events in Adults over 45 Years of Age: A Longitudinal Study Based on the CHARLS and Kailuan Cohorts.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Triglyceride-glucose index combined with estimated pulse wave velocity improves stroke risk stratification in the CHARLS cohort.Scientific reports · 2025Article
- Association between estimated pulse wave velocity and mortality risk in patients with acute ischemic stroke.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
backgroundArterial stiffness is recognized as a new risk factor for stroke. However, the association between estimated pulse wave velocity (ePWV), a well-established indirect measure of arterial stiffness and stroke among older adults, remains incompletely investigated.
methodsThis study utilized data from 3 prospective, nationally representative cohorts: the Health and Retirement Study in the United States, the English Longitudinal Study of Aging in the United Kingdom, and the China Health and Retirement Longitudinal Study in China. ePWV was calculated based on age and mean arterial pressure. Cox proportional hazard models were used to compute hazard ratios and 95% CIs.
resultsThe final analysis included 6458 participants from the Health and Retirement Study (mean age: 66.99 years; 40.4% men), 6458 from the English Longitudinal Study of Aging (mean age: 66.32; 44.4% men), and 12 415 from the China Health and Retirement Longitudinal Study (mean age: 58.60; 46.2% men). Over follow-up periods of 10.28 years in the Health and Retirement Study, 9.95 years in the English Longitudinal Study of Aging, and 6.30 years in the China Health and Retirement Longitudinal Study, 624 (9.7%), 374 (5.8%), and 656 (5.3%) participants developed stroke, respectively. Fully adjusted Cox regression analysis revealed a significant association between ePWV and incident stroke across all cohorts (Health and Retirement Study: hazard ratio, 1.29 [95% CI, 1.24-1.35]; English Longitudinal Study of Aging: hazard ratio, 1.37 [95% CI, 1.28-1.46]; China Health and Retirement Longitudinal Study: hazard ratio, 1.20 [95% CI, 1.15-1.25]).
conclusionsThis study demonstrated that higher levels of ePWV were associated with increased risks of incident stroke among middle-aged and older populations. Arterial stiffness assessment through ePWV could potentially improve primary prevention and treatment strategies for stroke.
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