ArticleVeterinary medicine and science2025
TNFRSF1A and NCF1 May Act as Hub Genes in Mastitis.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Decoding the lncRNA landscape in bovine mastitis: insights into immune regulation and gene networks underlying host response.Journal of animal science and biotechnology · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBovine mastitis (BM) is a major source of morbidity among cattle, imposing a significant burden on the dairy industry. Understanding the molecular mechanisms that confer susceptibility to bovine mastitis offers potential for therapeutic targeting, but these mechanisms remain complex and incompletely understood.
objectivesThis study aims to identify key molecular players and regulatory networks involved in bovine mastitis by integrating multiple expression datasets and applying network analysis.
methodsWe integrated data from three BM expression datasets and applied weighted gene co-expression network analysis (WGCNA) to identify specific modules and hub genes related to BM. Within the module that best correlated with mastitis, we constructed a network of mRNA-miRNA and protein-protein interactions.
resultsOur analysis revealed that TNFRSF1A and NCF1 are implicated as hub genes in the host's immune response to BM. Additionally, we identified bta-mir-2881 as a potential regulator of both TNFRSF1A and NCF1. These genes are crucial in regulating the immune response and defence against bacterial infections, highlighting their importance in mastitis susceptibility.
conclusionIdentifying miRNAs like bta-mir-2881 that may target key genes involved in mastitis susceptibility can shed light on the molecular mechanisms underlying the disease. This provides new targets for BM prevention and treatment, potentially alleviating the significant burden of the disease on the dairy industry.
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