Evidence map›Paper›PMID 40028743›Full record

Trial reportRegenerative medicine

Quality of life changes in patients suffering from knee osteoarthritis treated with bone marrow aspirate concentrate, platelet-rich plasma and hyaluronic acid injections.

Oliver Dulic, Dzihan Abazovic, Sara Matijevic, Predrag Rasovic, Mirko Obradovic, Mile Bjelobrk, Milan Tosic, Ivica Lalic, Branko Baljak, Milan Milinkov

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Regenerative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03825133 (The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03825133 phase4completednot on this map

The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial

TypeinterventionalSponsorClinical Center of VojvodinaRan2016 to 2017Enrolled180ConditionsKnee OsteoarthritisArmsBone Marrow Aspirate Concentrate, Leukocyte Rich Platelet Rich Plasma, Hyaluronic Acid
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Oliver DulicMedical Faculty, University of Novi Sad, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Dzihan AbazovicAtlas Hospital, Belgrade, Serbia.
Sara MatijevicBig Data Institute, University of Oxford, Oxford, UK.
Predrag RasovicMedical Faculty, University of Novi Sad, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Mirko ObradovicMedical Faculty, University of Novi Sad, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Mile BjelobrkMedical Faculty, University of Novi Sad, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Milan TosicMedical Faculty, University of Novi Sad, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Ivica LalicFaculty of Farmacy, University Business Academy, Novi Sad, Serbia.
Branko BaljakMedical Faculty, University of Novi Sad, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Milan MilinkovMedical Faculty, University of Novi Sad, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to compare the effects of different treatments on quality of life in knee osteoarthritis patients. It focused on three therapies: bone marrow aspirate concentrate (BMAC), platelet-rich plasma (PRP), and hyaluronic acid (HA). METHODOLOGY: The trial was conducted at a single center with 175 patients over a 12-month period with the knee OA, KL grade II-IV. Outcomes were measured using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and SF-36 scales, which assess physical and emotional well-being. Linear mixed models (LMMs) were used to analyze which treatment had the most positive impact on quality of life.

resultsPatients treated with BMAC showed the most substantial improvement, particularly in physical health and mobility (

conclusionsThe study suggested that BMAC treatment may contribute to improved quality of life in patients with knee osteoarthritis, particularly in terms of physical function. The correlation between WOMAC and SF-36 scores supports these findings, indicating a potential role for BMAC in enhancing mobility. CLINICAL

trial registrationNCT03825133 (ClinicalTrials.gov).

Indexed as

Bone Marrow TransplantationHyaluronic AcidOsteoarthritis, KneePlatelet-Rich PlasmaQuality of LifeAgedFemaleHumansMaleMiddle AgedTreatment OutcomeHyaluronic AcidBone marrow aspirate concentratehyaluronic acidknee osteoarthritisplatelet rich plasmaquality of liferegenerative orthopedics

Identifiers

PMID40028743
PMCPMC11951690

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.