Xanthogranulomatous Pyelonephritis in a Transplant Kidney Leading to Severe Allograft Dysfunction.

Usman Baig, Ahmad Mirza, Payaswini Vasanth, Laura Mulloy, Shameem Beigh, Imran Gani

Abstract readCase Reports

In one paragraph

Article in Case reports in transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Usman BaigDepartment of Nephrology, Hypertension and Transplant Medicine, Wellstar MCG Health, Augusta University, Augusta, Georgia, USA.

Ahmad MirzaDepartment of Surgery, Wellstar MCG Health, Augusta University, Augusta, Georgia, USA.

Payaswini VasanthDepartment of Nephrology, Emory University, Atlanta, Georgia, USA.

Laura MulloyDepartment of Nephrology, Hypertension and Transplant Medicine, Wellstar MCG Health, Augusta University, Augusta, Georgia, USA.

Shameem BeighDepartment of Nephrology, Hypertension and Transplant Medicine, Wellstar MCG Health, Augusta University, Augusta, Georgia, USA.

Imran GaniDepartment of Nephrology, Hypertension and Transplant Medicine, Wellstar MCG Health, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-4813-5022

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xanthogranulomatous pyelonephritis (XPN) is a rare and unusual form of pyelonephritis that infrequently occurs in renal allografts. Clinical presentation ranges from asymptomatic to fever, pyuria, and graft dysfunction. We present a case of a young African American male who presented with a marked elevation in serum creatinine from a baseline of 1.8-1.9 to 9.86 mg/dL. Transplant kidney biopsy was consistent with the diagnosis of XPN, showing xanthoma cells, which are pathognomonic for this condition. Following antibiotic treatment, allograft function improved and return to dialysis was averted. Clinicians should consider XPN in transplant patients with deteriorating allograft function, as its presentation can mimic more common conditions. Graft salvage with appropriate antimicrobial therapy should be attempted before considering nephrectomy which risks reinitiation of dialysis.

Indexed as

kidney transplantationrenal allograft dysfunctionurinary tract infectionxanthogranulomatous pyelonephritis

Identifiers

PMID40028629

DOI10.1155/crit/6605652

PMCPMC11870757

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