Evidence map›Paper›PMID 40028590›Full record

ArticleHeliyon2025

Optimization of regions of interest sampling strategies for proton density fat-fraction MRI of hepatic steatosis before liver transplantation in ex vivo livers.

Gen Chen, Hao Tang, Yang Yang, Lifen Zhou, Qiuxia Wang, Daoyu Hu, Zhen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  7. Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gen ChenDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Hao TangDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Yang YangDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Lifen ZhouDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Qiuxia WangDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Daoyu HuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Zhen LiDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The quantity of regions of interest (ROIs) constitutes the primary determinant of the time investment in image analysis. In the context of proton density fat-fraction (PDFF) magnetic resonance imaging (MRI) conducted on liver grafts in ex vivo conditions, this research systematically examines various ROI sampling strategies. The findings of this study furnish essential insights, offering a foundation for optimizing time efficiency while ensuring precise assessment of hepatic steatosis before the crucial process of liver transplantation. Methods: This was a retrospective analysis of a prospective study and included 35 liver grafts with histopathological steatosis that underwent 3T PDFF MRI in ex vivo. One ROI of 1 cm Results: The average 9-ROI PDFF of all liver grafts was 4.07 ± 4.35 % (0.870-20.904). All strategies with ≥5 ROIs had intraclass correlation coefficient (ICC) ≥ 0.995 and absolute limits of agreement (|LOA|)≤ 1.5 %. Overall, 54 of 84 (67.5 %) 3-ROI sampling strategy had ICC ≥0.995, and 70 of 84 (70 %) had |LOA|≤ 1.5 %. A total of 111 of 126 (88.1 %) 4-ROI sampling strategy had ICC ≥0.995, and 125 of 126 (99.2 %) had |LOA| ≤ 1.5 %. Conclusions: The employment of the 5-ROI sampling strategy proves instrumental in both time conservation and precise assessment of hepatic steatosis within liver grafts during the ex vivo phase preceding liver transplantation.

Indexed as

Hepatic steatosisLiver transplantationProton density fat fractionSampling strategy

Identifiers

PMID40028590
PMCPMC11872435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.