Evidence map›Paper›PMID 40028522›Full record

ReviewHeliyon2025

Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications.

Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

Abstract readReview
In one paragraph

Review in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  4. Article
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  6. Review
  7. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Microbial extracellular vesicles in the lung: friends in health, agents in disease.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  14. Review
  15. Review
  16. Towards EffectiveInternational journal of molecular sciences · 2025
    Review
  17. Review
  18. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2025
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mariam RimaLaboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, 1300, Tripoli, Lebanon.
Mariam DakramanjiDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Elie El HayekDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Tia El KhouryDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Ziad FajlounLaboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, 1300, Tripoli, Lebanon.
Mohamad RimaDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs), are critical mediators of intercellular communication and exhibit significant potential across various biomedical domains. These nano-sized, membrane-encapsulated entities have captured substantial interest due to their diverse roles in pathogenesis and promising therapeutic applications. EVs manage numerous physiological processes by transferring bioactive molecules, including proteins, lipids, and nucleic acids, between cells. This review delves into the factors influencing the properties of EVs, such as temperature and stress conditions, which collectively influence their size, composition, and functional attributes. We also describe the emerging roles of EVs, emphasizing their involvement in microbial interactions, immune modulation, antimicrobial resistance spread and their potential as innovative diagnostic and therapeutic instruments. Despite their promising applications, the advancement of EV-based therapies faces several challenges, which will also be discussed. By elucidating these critical elements, we aim to provide a comprehensive overview of the transformative potential of EVs in revolutionizing diagnostics and therapeutics in medicine.

Indexed as

Antimicrobial resistanceBiofilmDrug deliveryExtracellular vesicles

Identifiers

PMID40028522
PMCPMC11869109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.