Evidence map›Paper›PMID 40028474›Full record

ArticleMolecular biology research communications2025

The effect of chemotherapeutic agents on epidermal neural crest stem cells.

Nasim Rahmani-Kukia, Fatemeh Keshavarzi, Mohammad Saied Salehi, Farzaneh Bozorg-Ghalati, Zahra Mojtahedi, Mozhdeh Zamani, Negar Azarpira, Pooneh Mokarram

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Article in Molecular biology research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nasim Rahmani-KukiaAutophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Fatemeh KeshavarziMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Mohammad Saied SalehiClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Farzaneh Bozorg-GhalatiAutophagy Research Center, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra MojtahediSchool of Public Health, University of Nevada, Las Vegas, NV 89154, USA.
Mozhdeh ZamaniAutophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Negar AzarpiraAutophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Pooneh MokarramAutophagy Research Center, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human Epidermal Neural Crest Stem Cells (hEPI-NCSCs), as a transient population of multipotent migratory stem cells can differentiate into multiple types of neural and non-neural cells and tissues in the body. Here, we tried to determine the role of chemo agents in mediating the stress induced pathways like autophagy and unfolded protein responses (UPR), as well as the migratory potential of NCSCs. hEPI-NCSCs were treated with chemo agents including Dithiothreitol [(DTT) 10µM)], Salinomycin (9mM), Ebselen (10mM), 5-Fluorouracil [(5-FU) 8µM] and Cisplatin (6mM) for 72 hours. The reverse transcription-quantitative polymerase chain reaction (RT- qPCR) and scratch wound healing assays were used to assess the effect of chemo agents on NCSCs function. After treatment with DTT, hEPI-NCSCs upregulated the expression of genes related to autophagy and UPR pathways including

Indexed as

AutophagyChemo agentsNeural Crest Stem CellsUnfolded protein responses

Identifiers

PMID40028474
PMCPMC11865930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.