ArticleCureus2025
Beyond Infection: A Case of Doxycycline-Induced Mania and Prolonged Neuropsychiatric Disturbance.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doxycycline is commonly used in respiratory medicine to treat bacterial lower respiratory tract infections and is also a frequent choice in dermatology for various skin conditions. However, neuropsychiatric adverse reactions to doxycycline are rarely documented in the literature. Even less frequently reported is the persistence of such reactions for up to six weeks after discontinuing a 100 mg doxycycline tablet. We present a rare case of doxycycline-induced mania and psychosis in a patient who had taken the antibiotic for only three days, yet experienced severe neuropsychiatric symptoms that lasted for six weeks after treatment cessation. This case highlights the need for further research to identify the underlying mechanisms, high-risk populations, and implications for informed consent and clinical recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.