Evidence map›Paper›PMID 40028367›Full record

ArticleACS central science2025

Bio-orthogonal Glycan Imaging of Cultured Cells and Whole Animal

Joe Chin-Hun Kuo, Marshall J Colville, Michelle R Sorkin, Jacky Lok Ka Kuo, Ling Ting Huang, Dana N Thornlow, Gwendolyn M Beacham, Gunther Hollopeter, Matthew P DeLisa, Christopher A Alabi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Joe Chin-Hun KuoRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
Marshall J ColvilleRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0002-5397-8382
Michelle R SorkinRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
Jacky Lok Ka KuoRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
Ling Ting HuangRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
Dana N ThornlowRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
Gwendolyn M BeachamDepartment of Molecular Medicine, Cornell University, Ithaca, New York 14853, United States.
Gunther HollopeterDepartment of Molecular Medicine, Cornell University, Ithaca, New York 14853, United States.
Matthew P DeLisaRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
Christopher A AlabiRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0003-2654-018X
Matthew J PaszekRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.ORCID https://orcid.org/0000-0003-0064-9400

Funding

Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
Molecular toolkit for high content resolution of glycomes by expansionmicroscopyR01GM137314 · NIGMS · CORNELL UNIVERSITY · PI ALABI, CHRISTOPHER AKINLEYE, DELISA, MATTHEW P · 2020 to 2023
$1.8M
Biophysical regulation of intercellular communication by the glycocalyxR01GM138692 · NIGMS · CORNELL UNIVERSITY · PI PASZEK, MATTHEW J · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM137314NIGMS NIH HHS R01 GM138692NIH HHS R24 OD010943
6 · The paper itself

Abstract

Complex carbohydrates called glycans play crucial roles in regulating cell and tissue physiology, but how they map to nanoscale anatomical features must still be resolved. Here, we present the first nanoscale map of mucin-type

Identifiers

PMID40028367
PMCPMC11868961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.