ArticleAnalytical science advances2025
Simultaneous Determination of Residual Contamination of Eight Antineoplastic on Surfaces by HILIC Chromatography Coupled to High-Resolution Spectrometry.
Article in Analytical science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Residual contamination by intravenous antineoplastic drugs on hospital surfaces remains a critical concern, as highlighted by numerous studies. This study presents a novel, rapid and highly sensitive analytical method for quantifying a wide range of antineoplastic drugs and detecting other potentially harmful molecules on wiped surfaces. Utilizing hydrophilic interaction liquid chromatography (HILIC) coupled with high-resolution spectrometry, the method combines the quantification of eight commonly used antineoplastic drugs: 5-fluorouracil, ifosfamide, cyclophosphamide, gemcitabine, doxorubicin, methotrexate, epirubicin and irinotecan, with the identification of unknown compounds offering a comprehensive solution for monitoring hospital surface contamination. While HILIC-MS/MS has been extensively applied in various matrices, its use for surface contamination monitoring in healthcare settings has been relatively underexplored. Chromatographic separation was achieved using gradient elution on an HILIC ZORBAX 120 column (150 mm × 2.1 mm, 4 µm), enabling rapid analysis within 8 min. The method demonstrated exceptional sensitivity, achieving limits of quantification below 0.04 ng/cm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.