ArticleFrontiers in nutrition2025
Association between advanced lung cancer inflammation index and acute gouty arthritis in Dalian, China: a cross-sectional study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The association of the advanced lung cancer inflammation index with the risk ofFrontiers in cellular and infection microbiology · 2026Article
- Prognostic significance of advanced lung cancer inflammation index in resectable pancreatic cancer: A retrospective study.World journal of gastrointestinal surgery · 2025Article
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Authors and funding
3 authors.
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Abstract
Introduction: Acute gouty arthritis (AGA) is an inflammatory joint disease. The advanced lung cancer inflammation index (ALI) evaluates inflammation. This study investigates the association between ALI and AGA. Methods: We included 652 participants in this cohort study, dividing them into two groups: those with AGA and a control group without AGA. We employed logistic regression to examine the ALI-AGA relationship, using restricted cubic splines (RCS) to assess dose-response relationships, performing subgroup analyses, and conducting interaction tests. K-fold cross-validation was applied for model assessment. Receiver operating characteristic (ROC) curves were applied to visualize and compare the predictive value of ALI and other inflammatory indices for AGA. Results: Among the 652 participants, the AGA group exhibited significantly lower ALI values compared to the control group. Multivariate logistic regression identified an inverse relationship between ALI and AGA. RCS analysis indicated an L-shaped non-linear relationship between ALI levels and AGA, with inflection points at an ALI of 23.38. Subgroup analyses showed no significant interactions between ALI levels and AGA after stratifying by age, hypertension, coronary heart disease (CHD), and diabetes (DM). The results from the ROC curves indicate that ALI may serve as a better predictor of AGA. Conclusion: This cross-sectional study found a significant inverse correlation between ALI levels and AGA prevalence. Moreover, the ALI could serve as a more accurate diagnostic tool for AGA and offer a novel approach for further investigating the relationship between inflammation and AGA.
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