Evidence map›Paper›PMID 40028167›Full record

ArticleFrontiers in pharmacology2025

Jiao Zhang, Rui Zi, Ping Hu, Zongying Jiang, Ye Lv, Haixia Zhang, Yanjiao Zhao, Yan Wang, Lujun Zhao

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiao ZhangDepartment of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Rui ZiThe First Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China.
Ping HuThe First Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China.
Zongying JiangDepartment of Pathology, General Hospital of Ningxia Medical University, Yinchuan, China.
Ye LvThe Third Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China.
Haixia ZhangThe Third Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China.
Yanjiao ZhaoThe Third Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China.
Yan WangThe Third Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China.
Lujun ZhaoDepartment of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer. Basal membrane (BM) is important to the invasive processes of LUAD. Our object is to explore hub BM-related genes in LUAD. Methods: The gene expression data of LUAD were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The weighted gene co-expression network analysis and differentially expressed gene analysis were used to identify candidates. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were used to evaluate their functions. Univariate Cox regression analysis was used to evaluate the prognostic value, and multivariate Cox regression analysis was used to verify its independence as a prognostic risk factor. The qPCR and Western blot were performed to ascertain the hub gene expression. The survival curve of two groups was drawn using Kaplan-Meier method. The hub gene-related immune characteristics were analyzed in independent cohorts by ESTIMATE and CIBERSORT methods. Results: We successfully identified Discussion: Our study identified

Indexed as

basal membraneCOL7A1immune cell infiltrationimmunotherapylung adenocarcinomaprognosis

Identifiers

PMID40028167
PMCPMC11868062

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.