Evidence map›Paper›PMID 40028103›Full record

ArticleACS omega2025

Novel Benzimidazole-Oxadiazole Derivatives as Anticancer Agents with VEGFR2 Inhibitory Activity: Design, Synthesis, In Vitro Anticancer Evaluation, and In Silico Studies.

Ulviye Acar Çevik, Ismail Celik, Şennur Görgülü, Zeynep Deniz Şahin İnan, Hayrani Eren Bostancı, Arzu Karayel, Yusuf Özkay, Zafer Asım Kaplancıklı

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review of promising benzimidazole-based anticancer agents (2023-2026).Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ulviye Acar ÇevikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.ORCID https://orcid.org/0000-0003-3537-2544
Ismail CelikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey.ORCID https://orcid.org/0000-0002-8146-1663
Şennur GörgülüMedicinal Plant, Drug and Scientific Research and Application Center (AUBIBAM), Anadolu University, Eskişehir 26470, Turkey.
Zeynep Deniz Şahin İnanDepartment of Histology and Embryology, Sivas Cumhuriyet University, Sivas 58140, Turkey.
Hayrani Eren BostancıDepartment of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas 58140, Turkey.ORCID https://orcid.org/0000-0001-8511-2316
Arzu KarayelDepartment of Physics, Faculty of Arts and Science, Hitit University, Çorum 19030, Turkey.
Yusuf ÖzkayDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.
Zafer Asım KaplancıklıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this research is the synthesis of benzimidazole-1,3,4-oxadiazole derivatives that could be potential anticancer leads inhibiting VEGFR2. The compounds were evaluated for their cytotoxicity against cancer cell lines PANC-1, MCF-7, and A549 using the MTT assay. Two different normal cell lines (hTERT-HPNE and CCD-19Lu) were used to calculate the selectivity indices of the compounds. Compound

Identifiers

PMID40028103
PMCPMC11866186

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.