ReviewACS omega2025
Transgenic Innovation: Harnessing Cyclotides as Next Generation Pesticides.
Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026Review
- Chemotyping ofPlants (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclotides are unique cyclic mini proteins derived from plants which are recognized for the distinctive cyclic cystine knot (CCK) structure and the cyclized backbone. To date, more than 760 sequences of cyclotides have been identified across five major families, making them the largest known group of cyclic peptides. These cyclic peptides derived from plants have garnered significant attention due to their remarkable structural stability and diverse bioactivities, including potent insecticidal properties, which offer a promising alternative to conventional pesticides that are often associated with environmental toxicity and resistance development in pests. Advances in transgenic technology have opened new avenues for the sustainable and targeted deployment of cyclotides in pest management. By incorporating cyclotide genes into crops, plants can gain enhanced self-defense mechanisms against insect pests, reducing reliance on chemical pesticides and mitigating ecological impact. This review explores the molecular features essential in cyclotides' insecticidal activity, the latest breakthroughs in transgenic strategies for cyclotide expression in crops, and the potential challenges and future prospects of this innovative approach. By highlighting the synergy between natural bioactive compounds and genetic engineering, this work underscores the potential of cyclotides as next-generation, eco-friendly biopesticides to address global agricultural challenges.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.