ArticleWorld journal of orthopedics2025
Novel association between chronic obstructive pulmonary disease and osteoporosis: A prospective cross-sectional study.
Article in World journal of orthopedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development of a Clinical Nomogram for Predicting Densitometric Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease Based on NHANES Data.International journal of chronic obstructive pulmonary disease · 2026Article
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Authors and funding
5 authors.
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Abstract
backgroundChronic obstructive pulmonary disease (COPD) is a progressive respiratory condition often associated with a high incidence of osteoporosis. Studies indicate that patients with COPD present with a significant decrease in bone mineral density (BMD), potentially related to inflammation and corticosteroid use.
aimTo investigate the relationship between BMD and lung function, mainly the forced expiratory volume in the forced expiratory volume in 1 second (FEV1)/ forced vital capacity percentage (FVC%), in patients with COPD using quantitative computed tomography (QCT).
methodsThis prospective cross-sectional study included 85 patients with COPD treated at Gansu Provincial People's Hospital. Exposure variables included lung function parameter (FEV1/FVC%), age, sex, body mass index, smoking status, tea-drinking habits, and physical activity. BMD was measured using QCT. Linear regression and generalized additive models were employed to analyze the relationship between exposure variables and BMD.
resultsLinear regression analysis revealed a significant positive relationship between BMD and FEV1/FVC% (
conclusionThere is a complex non-linear relationship between BMD and lung function in patients with COPD, highlighting the importance of monitoring change in bone density during the management of COPD.
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