Evidence map›Paper›PMID 40027791›Full record

ArticlebioRxiv : the preprint server for biology2025

Composition and RNA binding specificity of metazoan RNase MRP.

Yuan Liu, Shiyang He, Anzie Pyo, Shanshan Zheng, Meijuan Chen, Sihem Cheloufi, Nikolai Slavov, William F Marzluff, Jernej Murn

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yuan LiuDepartment of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA 92521, U.S.A.
Shiyang HeDepartment of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA 92521, U.S.A.ORCID 0000-0002-1849-2635
Anzie PyoDepartment of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA 92521, U.S.A.
Shanshan ZhengDepartments of Bioengineering, Biology, Chemistry, and Chemical Biology, Single Cell Proteomics Center, and Barnett Institute, Northeastern University, Boston, Massachusetts 02115, USA.
Meijuan ChenDepartment of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA 92521, U.S.A.
Sihem CheloufiDepartment of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA 92521, U.S.A.ORCID 0000-0002-1726-4796
Nikolai SlavovDepartments of Bioengineering, Biology, Chemistry, and Chemical Biology, Single Cell Proteomics Center, and Barnett Institute, Northeastern University, Boston, Massachusetts 02115, USA.ORCID 0000-0003-2035-1820
William F MarzluffIntegrated Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.ORCID 0000-0003-3635-4073
Jernej MurnDepartment of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall, Riverside, CA 92521, U.S.A.ORCID 0000-0002-1729-5859

Funding

Investigating the molecular mechanisms of early neuronal morphogenesisR01GM144693 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Jernej Murn · 2022 to 2026
$1.7M
Investigating the Regulatory Roles of Histone Chaperones in Cellular PlasticityR35GM151004 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Sihem Cheloufi · 2023 to 2026
$1.6M
Molecular and metabolic influences on the activation of monocytes and macrophages at single-cell resolutionR35GM148218 · NIGMS · NORTHEASTERN UNIVERSITY · PI Nikolai Slavov · 2023 to 2026
$1.5M
NIGMS NIH HHS R01 GM144693NIGMS NIH HHS R35 GM148218NIGMS NIH HHS R35 GM151004
6 · The paper itself

Abstract

Ribonuclease (RNase) MRP is a conserved RNA-based enzyme that is essential for maturation of ribosomal RNA (rRNA) in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein complex in higher eukaryotes remain a mystery. Here, we identify NEPRO and C18ORF21 as constitutive subunits of metazoan RNase MRP. Both proteins are specific to RNase MRP and are the only ones distinguishing this enzyme from the closely related RNase P, which selectively cleaves transfer RNA-like substrates. We find that NEPRO and C18ORF21 each form a complex with all other subunits of RNase MRP, stabilize its catalytic RNA, and are required for rRNA maturation and cell proliferation. We harness our discovery to identify a full suite of

Identifiers

PMID40027791
PMCPMC11870539

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.