Evidence map›Paper›PMID 40027789›Full record

ArticlebioRxiv : the preprint server for biology2025

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of

Trevor Cross, Facundo Torres, Abigail P McGee, Tolani Aliyu, Lars F Westblade, Abhyudai Singh, Tobias Dörr

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Trevor CrossDepartment of Microbiology, Cornell University, Ithaca, NY.
Facundo TorresDepartment of Microbiology, Cornell University, Ithaca, NY.
Abigail P McGeeWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY.
Tolani AliyuWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY.
Lars F WestbladeDepartments of Pathology and Laboratory Medicine, Medicine, and Pediatrics, Weill Cornell Medicine, New York, NY.
Abhyudai SinghDepartment of Electrical and Computer Engineering, University of Delaware, Newark, DE, 19716, USA.
Tobias DörrDepartment of Microbiology, Cornell University, Ithaca, NY.ORCID 0000-0003-3283-9161

Funding

Cell envelope stress responses and the mechanism of antibiotic tolerance in Gram-negative pathogensR01AI143704 · NIAID · CORNELL UNIVERSITY · PI DOERR, TOBIAS · 2019 to 2023
$2.0M
Generalized fluctuation test for deciphering phenotypic switching within cell populationsR35GM148351 · NIGMS · UNIVERSITY OF DELAWARE · PI Abhyudai Singh · 2023 to 2026
$1.6M
NIAID NIH HHS R01 AI143704NIGMS NIH HHS R35 GM148351
6 · The paper itself

Abstract

Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, often exhibit high tolerance to the last-resort antibiotic meropenem. Meropenem tolerance is associated with formation of cell wall-deficient spheroplasts that readily recover to rod shape and normal growth upon removal of the antibiotic. Both the true prevalence of tolerance, and genetic mechanisms underlying it, remain poorly understood. Here, we find that meropenem tolerance is widespread among clinical Enterobacterales. Using forward genetics, we uncover novel tolerance factors in a hypertolerant isolate of the ESKAPE pathogen

Indexed as

cell envelope stress responseL-formmeropenemMltBspheroplast

Identifiers

PMID40027789
PMCPMC11870580

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.