ArticlebioRxiv : the preprint server for biology2025
Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.
Lisa Blackmer-Raynolds, Maureen M Sampson, Anna Kozlov, Aimee Yang, Lyndsey Lipson, Adam M Hamilton, Sean D Kelly, Pankaj Chopra, Jianjun Chang, Steven A Sloan and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Lisa Blackmer-RaynoldsDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322.
Maureen M SampsonDepartment of Human Genetics, Emory University School of Medicine, Atlanta GA 30322.
Anna KozlovDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322.
Aimee YangDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322.
Lyndsey LipsonDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322.
Adam M HamiltonDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322.
Sean D KellyDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322.
Pankaj ChopraDepartment of Human Genetics, Emory University School of Medicine, Atlanta GA 30322.
Jianjun ChangDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322.
Steven A SloanDepartment of Human Genetics, Emory University School of Medicine, Atlanta GA 30322.
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MTraining In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9MMolecular Drivers of Human GliogenesisR01MH125956 · NIMH · EMORY UNIVERSITY · PI SLOAN, STEVEN A · 2021 to 2025
$3.0MInteraction of Pyrethroid Exposure and the Microbiome on Parkinson's Disease related PathologiesR01ES032440 · NIEHS · EMORY UNIVERSITY · PI Timothy Robert Sampson · 2022 to 2026
$1.7MNeuron-Astrocyte Interactions in Developmental Lead ExposureK00ES033033 · NIEHS · EMORY UNIVERSITY · PI SAMPSON, MAUREEN MCGUIRK · 2020 to 2023
$339kMicrobiome-microglia interactions in Alzheimer’s disease pathophysiologyF31AG076332 · NIA · EMORY UNIVERSITY · PI BLACKMER-RAYNOLDS, LISA · 2023 to 2024
$97kNCATS NIH HHS UL1 TR002378NIA NIH HHS F31 AG076332NIEHS NIH HHS K00 ES033033NIEHS NIH HHS R01 ES032440NIMH NIH HHS R01 MH125956NINDS NIH HHS T32 NS096050
6 · The paper itselfAbstract
The native microbiome influences a plethora of host processes, including neurological function. However, its impacts on diverse brain cell types remains poorly understood. Here, we performed single nucleus RNA sequencing on hippocampi from wildtype, germ-free mice and reveal the microbiome-dependent transcriptional landscape across all major neural cell types. We found conserved impacts on key adaptive immune and neurodegenerative transcriptional pathways, underscoring the microbiome's contributions to disease-relevant processes. Mono-colonization with select indigenous microbes identified species-specific effects on the transcriptional state of brain myeloid cells. Colonization by
Identifiers
PMID40027785
PMCPMC11870502
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