Evidence map›Paper›PMID 40027763›Full record

ArticlebioRxiv : the preprint server for biology2025

Effects of Lamina-Chromatin Attachment on Super Long-Range Chromatin Interactions.

Pourya Delafrouz, Hammad Farooq, Lin Du, Ao Ma, Jie Liang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Pourya DelafrouzRichard and Loan Hill Dept of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607.
Hammad FarooqRichard and Loan Hill Dept of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0001-5691-298X
Lin DuRichard and Loan Hill Dept of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0009-0002-8986-9812
Ao MaRichard and Loan Hill Dept of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607.
Jie LiangRichard and Loan Hill Dept of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-2773-6427

Funding

Models and Algorithms for Biological Networks and Polymers: Stochastic Probability Landscape and Chromatin EnsemblesR35GM127084 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIANG, JIE · 2018 to 2025
$3.7M
Predicting 3D physical gene-enhancer interactions through integration of GTEx and 4DN dataR03OD036492 · OD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIANG, JIE · 2023 to 2023
$298k
NIGMS NIH HHS R35 GM127084NIH HHS R03 OD036492
6 · The paper itself

Abstract

The interactions between chromatin and lamin proteins localized on the nuclear envelope play a crucial role in the three-dimensional (3D) organization of the genome. This study investigates the influence of lamin associated domains (LADs) on genome organization at the chromosome level using 3D polymer models of mouse embryonic fibroblasts (MEFs) and embryonic stem cells (mESCs). By integrating genome-wide LAD maps from DamID assays, we simulated chromatin conformations with and without LAD attachment to the nuclear envelope. Our results show that incorporating LAD-lamin interactions yields a radial chromatin distribution consistent with experimental observations. Moreover, LAD-lamin interactions induce significant super long-range chromatin contacts across distant genomic regions. These findings suggest two distinct mechanisms driving induction of chromatin interactions by LAD-lamin attachment.

Indexed as

3D single cell conformationsGenome organizationLamina Associated Domain

Identifiers

PMID40027763
PMCPMC11870427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.