Evidence map›Paper›PMID 40027761›Full record

ArticlebioRxiv : the preprint server for biology2025

A Critical Role for the Fascin Family of Actin Bundling Proteins in Axon Development, Brain Wiring and Function.

Katherine R Hardin, Arjolyn B Penas, Shuristeen Joubert, Changtian Ye, Kenneth R Myers, James Q Zheng

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Katherine R Hardin
Arjolyn B Penas
Shuristeen Joubert
Changtian Ye
Kenneth R Myers

Funding

Fascin in brain development and functionR21NS132393 · NINDS · EMORY UNIVERSITY · PI ZHENG, JAMES Q · 2023 to 2024
$415k
Fascin1 in Growth Cone Motility and GuidanceF31NS127574 · NINDS · EMORY UNIVERSITY · PI HARDIN, KATHERINE REBECCA · 2023 to 2024
$97k
NINDS NIH HHS F31 NS127574NINDS NIH HHS R21 NS132393
6 · The paper itself

Abstract

Actin-based cell motility drives many neurodevelopmental events including guided axonal growth. Fascin is a major family of F-actin bundling proteins, but its role in axon development Highlights: Fascin regulates axon growth and branching of hippocampal neurons in culture. Singed, a

Identifiers

PMID40027761
PMCPMC11870622

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.