Evidence map›Paper›PMID 40027749›Full record

ArticlebioRxiv : the preprint server for biology2025

Amniotic Fluid Reduces Liver Fibrosis By Attenuating Hepatic Stellate Cell Activation.

Charles M Bowen, Frederick Ditmars, Naiyou Liu, Jose Marri Abril, David Ajasin, William K Russell, Heather L Stevenson, Eliseo A Eugenin, Jeffrey H Fair, W Samuel Fagg

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Charles M BowenDivision of Transplant, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Frederick DitmarsDivision of Transplant, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Naiyou LiuDivision of Transplant, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Jose Marri AbrilDivision of Transplant, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
David AjasinDepartment of Neurobiology, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
William K RussellDeparment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Heather L StevensonDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, 77555, USA.ORCID 0000-0002-0645-7621
Eliseo A EugeninDepartment of Neurobiology, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
Jeffrey H FairDivision of Transplant, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, 77555, USA.
W Samuel FaggDivision of Transplant, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, 77555, USA.ORCID 0000-0003-2909-1666

Funding

UTMB Clinical and Translational Science AwardKL2TR001441 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI AMEREDES, BILL T · 2015 to 2024
$4.0M
UTMB Clinical and Translational Science AwardTL1TR001440 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HOMMEL, JONATHAN DEAN · 2015 to 2024
$3.4M
Role of pannexin-1 hemichannels in NeuroAIDSR01NS105584 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2017 to 2021
$3.2M
Metabolic strategies to eliminate CNS Myeloid Viral ReservoirsR01MH128082 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2021 to 2025
$3.1M
Targeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirsR01MH134761 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Eliseo A Eugenin · 2024 to 2026
$2.1M
NCATS NIH HHS KL2 TR001441NCATS NIH HHS TL1 TR001440NIMH NIH HHS R01 MH128082NIMH NIH HHS R01 MH134761NINDS NIH HHS R01 NS105584
6 · The paper itself

Abstract

Regardless of the source of injury or metabolic dysfunction, fibrosis is a frequent driver of liver pathology. Excessive liver fibrosis is caused by persistent activation of hepatic stellate cells (HSCs), which is defined by myofibroblast activation (MFA) and the epithelial-mesenchymal transition (EMT). Strategies to prevent or reverse this HSC phenotype will be critical for successful treatment of liver fibrosis. We have previously shown that full-term, cell-free human amniotic fluid (cfAF) inhibits MFA and EMT in fibroblasts

Indexed as

amniotic fluidepithelial-mesenchymal transitionhepatic stellate cellLiver fibrosismyofibroblast activationregenerative medicine

Identifiers

PMID40027749
PMCPMC11870538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.