Evidence map›Paper›PMID 40027729›Full record

ArticlebioRxiv : the preprint server for biology2025

PRDM16 controls smooth muscle cell fate in atherosclerosis.

Josephine M E Tan, Lan Cheng, Ryan P Calhoun, Angela H Weller, Karima Drareni, Skylar Fong, Eirlys Barbara, Hee-Woong Lim, Chenyi Xue, Hanna Winter and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Josephine M E TanInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lan ChengInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ryan P CalhounInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Angela H WellerInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Karima DrareniInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Skylar FongInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eirlys BarbaraInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hee-Woong LimDepartment of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Chenyi XueDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, USA.
Hanna WinterInstitute of Molecular Vascular Medicine, University Hospital rechts der Isar, Technical University Munich, Germany.
Gaëlle AugusteDepartment of Genome Sciences; Department of Biochemistry and Molecular Genetics; University of Virginia, Charlottesville, VA 22908, USA.
Clint L MillerDepartment of Genome Sciences; Department of Biochemistry and Molecular Genetics; University of Virginia, Charlottesville, VA 22908, USA.
Muredach P ReillyDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, USA.
Lars MaegdefesselInstitute of Molecular Vascular Medicine, University Hospital rechts der Isar, Technical University Munich, Germany.
Esther LutgensExperimental Cardiovascular Immunology Laboratory, Department of Cardiovascular Medicine and Immunology, Mayo Clinic, Rochester, MN, USA.
Patrick SealeInstitute for Diabetes, Obesity & Metabolism; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Multimodal genetic regulatory architecture of coronary artery diseaseR01HL148239 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint L Miller · 2019 to 2026
$4.2M
Regulation of Mesenchymal Progenitor Cell Fate and Adipose Tissue RemodelingR01DK120982 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 2019 to 2026
$3.7M
Smooth muscle cell-derived cell fates and cellular interactions in atherosclerotic plaque stability in disease progression and regression.R01HL166916 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Muredach P Reilly · 2023 to 2026
$2.8M
Computational and functional strategies to decipher lncRNAs in human atherosclerosisR01HL150359 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LI, MINGYAO, REILLY, MUREDACH P · 2020 to 2023
$2.7M
Identification of smooth muscle cell genes causal in atherosclerotic plaque stability and cardiovascular disease riskR01HL169766 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Muredach P Reilly, Danish Saleheen · 2023 to 2026
$2.6M
Functional genomics investigation of pleiotropic vascular disease lociR01HL164577 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, CLINT L · 2022 to 2025
$2.3M
Metabolic Control of Adipose Tissue Remodeling and FibrosisR01DK123356 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEALE, PATRICK · 2019 to 2022
$1.9M
Fat and synovial tissue remodeling in joint osteoarthritisR21AR078650 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING, SEALE, PATRICK · 2021 to 2021
$393k
NHLBI NIH HHS R01 HL148239NHLBI NIH HHS R01 HL150359NHLBI NIH HHS R01 HL164577NHLBI NIH HHS R01 HL166916NHLBI NIH HHS R01 HL169766NIAMS NIH HHS R21 AR078650NIDDK NIH HHS R01 DK120982NIDDK NIH HHS R01 DK123356
6 · The paper itself

Abstract

Vascular smooth muscle cells (SMCs) normally exist in a contractile state but can undergo fate switching to produce various cell phenotypes in response to pathologic stimuli

Identifiers

PMID40027729
PMCPMC11870537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.