Evidence map›Paper›PMID 40027727›Full record

ArticlebioRxiv : the preprint server for biology2025

Cholesterol efflux protein, ABCA1, supports anti-cancer functions of myeloid immune cells.

Shruti V Bendre, Yu Wang, Basel Hajyousif, Rajendra K C, Shounak G Bhogale, Dhanya Pradeep, Natalia Krawczynska, Claire P Schane, Erin Weisser, Avni Singh and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Shruti V BendreDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0002-6391-8930
Yu WangDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0001-7815-2600
Basel HajyousifDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.
Rajendra K CCenter for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, University of Illinois at Urbana-Champaign, Illinois, USA.
Shounak G BhogaleDepartment of Computer Science, University of Illinois at Urbana-Champaign, Illinois, USA.
Dhanya PradeepDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.
Natalia KrawczynskaDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0002-1882-6009
Claire P SchaneDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0009-0004-1752-8829
Erin WeisserDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.
Avni SinghDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.
Simon HanDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.
Hannah KimDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.
Lara KockayaDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.
Anasuya Das GuptaDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0002-1273-0620
Adam T NelczykDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0001-7468-7835
Hashni Epa Vidana GamageDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0009-0002-0743-2896
Yifan FeiDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0003-1493-8019
Xingyu GuoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL, USA.
Ryan J DeatonResearch Histology and Tissue Imaging Core, University of Illinois at Chicago, Illinois, USA.
Maria SverdlovResearch Histology and Tissue Imaging Core, University of Illinois at Chicago, Illinois, USA.
Peter H GannResearch Histology and Tissue Imaging Core, University of Illinois at Chicago, Illinois, USA.ORCID 0000-0002-9439-2900
Saurabh SinhaDepartment of Computer Science, University of Illinois at Urbana-Champaign, Illinois, USA.
Kun WangDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Illinois, USA.
Kevin Van BortleDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Illinois, USA.
Emad TajkorshidBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0001-8434-1010
Wendy A WoodwardDepartment of Breast Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
Wonhwa ChoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL, USA.
Erik R NelsonDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA.ORCID 0000-0002-8887-1905

Funding

Research Training Program in Toxicology and Environmental HealthT32ES007326 · NIEHS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jodi A. Flaws · 2000 to 2026
$8.7M
Training Program at the Chemistry Biology InterfaceT32GM136629 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Paul Hergenrother · 2020 to 2026
$4.5M
Deciphering the Mechanism of Lymphovascular Space Invasion Using a Lymphovascularized Bioengineering Breast Stromal PlatformR01CA284102 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI Bisrat G Debeb, Marissa Nichole Rylander · 2024 to 2026
$3.3M
Molecular Determinants of Inflammatory Breast CancerR01CA264529 · NCI · DUKE UNIVERSITY · PI DEVI, GAYATHRI · 2021 to 2025
$2.5M
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
Translational Combinations of Nanocarriers and Blockers for Metastatic Breast CancerR01CA288207 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ERIK Russell NELSON, Andrew Michael Smith · 2024 to 2026
$1.7M
Impact of cholesterol and its metabolites on breast cancer progressionR01CA234025 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NELSON, ERIK RUSSELL · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA234025NCI NIH HHS R01 CA264529NCI NIH HHS R01 CA284102NCI NIH HHS R01 CA288207NIBIB NIH HHS T32 EB019944NIEHS NIH HHS T32 ES007326NIGMS NIH HHS T32 GM136629
6 · The paper itself

Abstract

Although immune therapy has seen significant advances, the majority of breast and other solid tumors do not respond or quickly develop

Identifiers

PMID40027727
PMCPMC11870514

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.