Evidence map›Paper›PMID 40027688›Full record

ArticlebioRxiv : the preprint server for biology2025

CHIP protects lysosomes from CLN4 mutant-induced membrane damages.

Juhyung Lee, Jizhong Zou, Wan Nur Atiqah Binti Mazli, Natalie Chin, Michal Jarnik, Layla Saidi, Yue Xu, John Replogle, Michael Ward, Juan Bonifacino and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Juhyung LeeLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3638-1496
Jizhong ZouiPSC Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Wan Nur Atiqah Binti MazliDepartment of Chemistry and Biochemistry, the University of Maryland, College Park, MD 20742, USA.
Natalie ChinLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Michal JarnikNeurosciences and Cellular and Structural Biology Division, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Layla SaidiLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Yue XuLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
John ReplogleNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Michael WardNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Juan BonifacinoNeurosciences and Cellular and Structural Biology Division, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Wei ZhengTherapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20850, USA.
Ling HaoDepartment of Chemistry and Biochemistry, the University of Maryland, College Park, MD 20742, USA.
Yihong YeLaboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Development of Mass Spectrometry Strategies to Decipher Dynamic Lysosomal Dysfunctions in Frontotemporal DementiaR01NS121608 · NINDS · UNIV OF MARYLAND, COLLEGE PARK · PI Ling Hao · 2021 to 2026
$2.0M
NINDS NIH HHS R01 NS121608
6 · The paper itself

Abstract

Understanding how cells mitigate lysosomal damage is critical for unraveling pathogenic mechanisms of lysosome-related diseases. Here we use organelle-specific proteomics in iPSC-derived neurons (i

Indexed as

autophagy/microautophagyCeroid Lipofuscinosis Neuronal/CLN4CHIP/STUB1DNAJC5/CSPαDrosophila disease modellysosome membrane damagelysosome storage disease/LSDneurodegenerative diseaseubiquitin

Identifiers

PMID40027688
PMCPMC11870535

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.